MW 481.8 Da, Purity >98%. Cell-permeable, phenylcyclohexyl-urea based compound that selectively downregulates the expression of p21, independent of p53 expression, at either transcription or post-transcriptional level. Attenuates p21 protein levels with minimal effect on p21 protein stability. Has no significant effect on the activities of Raf kinases, VEGFR2 kinase, or the phosphorylation state of ERK. Effectively inhibits the growth of multiple cancer cell lines (GI50 = ~ 10 μM against NCI60 cell lines).
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- Investigative ophthalmology & visual science 63:182022Znhit1 Regulates p21Cip1 to Control Mouse Lens Differentiation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJuan Lu,Jianhong An,Jiawei Wang,Xiaowen Cao,Yuqing Cao,Chengjie Huang,Shiming Jiao,Dongsheng Yan,Xinhua Lin,Xiangtian ZhouPubMed 35472217
- Cells 9:2020TFEB Modulates p21/WAF1/CIP1 during the DNA Damage Response.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSandra Pisonero-Vaquero et. al.PubMed 32397616
- Aging 12:3025-30412020Obg-like ATPase 1 (OLA1) overexpression predicts poor prognosis and promotes tumor progression by regulating P21/CDK2 in hepatocellular carcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShanzhou Huang et. al.PubMed 32045367
- Scientific reports 9:193412019Increased double strand breaks in diabetic β-cells with a p21 response that limits apoptosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesVanessa S Y Tay et. al.PubMed 31852915
Key facts
- CAS number
- 1394011-91-6
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 481.8 Da
- Molecular formula
- C20H18ClF6N3O2
- PubChem identifier
- 60196635
- Nature
- Synthetic
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MW 481.8 Da, Purity >98%. Cell-permeable, phenylcyclohexyl-urea based compound that selectively downregulates the expression of p21, independent of p53 expression, at either transcription or post-transcriptional level. Attenuates p21 protein levels with minimal effect on p21 protein stability. Has no significant effect on the activities of Raf kinases, VEGFR2 kinase, or the phosphorylation state of ERK. Effectively inhibits the growth of multiple cancer cell lines (GI50 = ~ 10 μM against NCI60 cell lines).
Key facts
- CAS number
- 1394011-91-6
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 481.8 Da
- Molecular formula
- C20H18ClF6N3O2
- PubChem identifier
- 60196635
- Nature
- Synthetic
- Solubility
Soluble in ethanol to 100 mM.
Soluble in DMSO to 100 mM.
- Biochemical name
- 1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[(1r,4r)-4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}cyclohexyl]urea
- Biological description
Cell-permeable, phenylcyclohexyl-urea based compound that selectively downregulates the expression of p21, independent of p53 expression, at either transcription or post-transcriptional level. Attenuates p21 protein levels with minimal effect on p21 protein stability. Has no significant effect on the activities of Raf kinases, VEGFR2 kinase, or the phosphorylation state of ERK. Effectively inhibits the growth of multiple cancer cell lines (GI50 = ~ 10 μM against NCI60 cell lines).
- Canonical SMILES
- C1CC(CCC1NC(=O)NC2=CC(=C(C=C2)Cl)C(F)(F)F)OC3=NC=C(C=C3)C(F)(F)F
- InChI
- InChI=1S/C20H18ClF6N3O2/c21-16-7-4-13(9-15(16)20(25,26)27)30-18(31)29-12-2-5-14(6-3-12)32-17-8-1-11(10-28-17)19(22,23)24/h1,4,7-10,12,14H,2-3,5-6H2,(H2,29,30,31)
- InChIKey
- ISPSOOYSNVVMMB-UHFFFAOYSA-N
- IUPAC name
- 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[4-[5-(trifluoromethyl)pyridin-2-yl]oxycyclohexyl]urea
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store in the dark
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1 product image
Chemical Structure - UC2288, p21 inhibitor (ab146969)
2D chemical structure image of ab146969, UC2288, p21 inhibitor
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