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AB146404

UCPH-102, EAAT1 inhibitor

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(3 Publications)

MW 330.39 g/mol, Purity >98%. Selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitor (IC50 = 0.42 μM). Active in vivo. Blood-brain barrier permeable analog of UCPH-101 (ab120309).
2 Images
Functional Studies - UCPH-102, EAAT1 inhibitor (AB146404)
  • FuncS

Unknown

Functional Studies - UCPH-102, EAAT1 inhibitor (AB146404)

Plot to compare the bioavailability of UCPH-102 in plasma versus brain.

Chemical Structure - UCPH-102, EAAT1 inhibitor (AB146404)
  • Chemical Structure

Lab

Chemical Structure - UCPH-102, EAAT1 inhibitor (AB146404)

2D chemical structure image of ab146404, UCPH-102, EAAT1 inhibitor

Key facts

CAS number

1229591-56-3

Purity

>98%

Form

Solid

form

Molecular weight

330.39 g/mol

Molecular formula

C<sub>2</sub><sub>1</sub>H<sub>1</sub><sub>8</sub>N<sub>2</sub>O<sub>2</sub>

Nature

Synthetic

Solubility

Soluble in DMSO to 25 mM. It is recommended that all preparations are centrifuged before use.

Biological description

Selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitor (IC50 = 0.42 μM). Active in vivo. Blood-brain barrier permeable analog of UCPH-101 (ab120309).

Canonical smiles

O=C1CC(CC=2OC(N)=C(C#N)C(C)C1=2)C4CCCC3CCCCC34

InChi

InChI=1S/C21H18N2O2/c1-12-17(11-22)21(23)25-19-10-14(9-18(24)20(12)19)16-8-4-6-13-5-2-3-7-15(13)16/h2-8,12,14H,9-10,23H2,1H3

InChiKey

XZQMHUGTNOOYFX-UHFFFAOYSA-N

IUPAC Name

2-Amino-5,6,7,8-tetrahydro-4-methyl-7-(1-naphthalenyl)-5-oxo-4H-1-benzopyran-3-carbonitrile

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

ChemMedChem 11:403-19 PubMed26797816

2016

Bioavailability Studies and in vitro Profiling of the Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitor UCPH-102.

Applications

Unspecified application

Species

Unspecified reactive species

Isabell Haym,Tri H V Huynh,Stinne W Hansen,Martin H F Pedersen,Josep A Ruiz,Mette N Erichsen,Mikko Gynther,Walden E Bjørn-Yoshimoto,Bjarke Abrahamsen,Jesper F Bastlund,Christoffer Bundgaard,Anette L Eriksen,Anders A Jensen,Lennart Bunch

Neurochemical research 39:1964-79 PubMed24682739

2014

Probing for improved potency and in vivo bioavailability of excitatory amino acid transporter subtype 1 inhibitors UCPH-101 and UCPH-102: design, synthesis and pharmacological evaluation of substituted 7-biphenyl analogs.

Applications

Unspecified application

Species

Unspecified reactive species

Mette N Erichsen,Jeanette Hansen,Josep A Ruiz,Charles S Demmer,Bjarke Abrahamsen,Jesper F Bastlund,Christoffer Bundgaard,Anders A Jensen,Lennart Bunch

Bioorganic & medicinal chemistry 20:6831-9 PubMed23072958

2012

Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102.

Applications

Unspecified application

Species

Unspecified reactive species

Tri H V Huynh,Bjarke Abrahamsen,Karsten K Madsen,Alba Gonzalez-Franquesa,Anders A Jensen,Lennart Bunch
View all publications
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Chemical Structure - UCPH-101, Selective EAAT1 inhibitor (AB120309)

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