MW 470.11 Da, Purity >98%. Endogenous P2Y receptor agonist which preferentially activates P2Y6. Antagonist and agonist activities reported at human P2Y14 receptors. Potent full agonist at rat P2Y12 (EC50 = 350 nM).
DKFZp686M18273, G-protein coupled receptor 17, GPR17_HUMAN, P2Y-like receptor, Probable P2Y purinoceptor GPR 17, R12, UDP/CysLT receptor, Uracil nucleotide/cysteinyl leukotriene receptor
MW 470.11 Da, Purity >98%. Endogenous P2Y receptor agonist which preferentially activates P2Y6. Antagonist and agonist activities reported at human P2Y14 receptors. Potent full agonist at rat P2Y12 (EC50 = 350 nM).
Soluble in water to 100 mM.
Endogenous P2Y receptor agonist which preferentially activates P2Y6. Antagonist and agonist activities reported at human P2Y14 receptors. Potent full agonist at rat P2Y12 (EC50 = 350 nM).
GPR17 also known as G protein-coupled receptor 17 is a member of the G protein-coupled receptor (GPCR) family. This receptor has a molecular weight of approximately 40 kDa. It is expressed in various tissues with significant levels found in the central nervous system including the brain and spinal cord. GPR17 also shows expression in kidneys liver and heart. It is classified under the class A Rhodopsin-like family and is an orphan receptor meaning its natural ligand is not completely established but is thought to be associated with uridine nucleotides and cysteinyl leukotrienes.
GPR17 is involved in several physiological processes particularly in the regulation of inflammation and myelination within the central nervous system. It plays a critical role in the differentiation of oligodendrocyte precursor cells into mature oligodendrocytes which are essential for myelin sheath formation and repair of neural damage. GPR17 is not known to function as part of a larger receptor complex but it interacts with intracellular signaling pathways to modulate these cellular processes.
GPR17 integrates into inflammatory response pathways and neural cell development pathways. It is actively involved in the nucleotide signaling pathway which is important for responses to tissue damage and initiating repair processes. GPR17 shares functional connections with proteins such as P2Y receptors which also respond to nucleotides and are involved in diverse cellular responses including muscle contraction and platelet aggregation.
GPR17's expression and role connect it to multiple sclerosis and brain ischemia. In multiple sclerosis dysregulation of GPR17 can affect the formation and maintenance of the myelin sheath contributing to neural degeneration. During brain ischemia GPR17 activation influences the extent of injury and subsequent recovery through its effects on inflammation and tissue repair. It is linked to proteins like CXCR7 which similarly influence neural damage and repair processes in ischemic conditions.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com