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AB142157

UNC0638, G9 and GLP histone methyltransferase inhibitor

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(0 Publication)

MW 509.7 Da, Purity >98%. Potent, selective and reversible G9 and GLP histone methyl transferase inhibitor (IC50 values are 15 and 19 nM respectively). Maintains HSC multipotency in vitro. Cell-permeable.

View Alternative Names

ADCADN, AIM, Ankyrin repeat containing protein, Bat 8, C6orf30, CXXC finger protein 9, CXXC-type zinc finger protein 9, CXXC9, DKFZp667M072, DKFZp686H08213, DNA (cytosine-5)-methyltransferase 1, DNA MTase, DNA MTase HsaI, DNA methyltransferase 1, DNA methyltransferase HsaI, DNA methyltransferase M.HsaI., DNMT, DNMT1_HUMAN, Dnmt1o, EHMT1_HUMAN, EHMT2_HUMAN, Eu-HMTase1, Euchromatic histone lysine methyltransferase 2, Euchromatic histone methyltransferase 1, Euchromatic histone-lysine N-methyltransferase 1, Euchromatic histone-lysine N-methyltransferase 2, FLJ12879, FLJ16293, FLJ35547, FP13812, G 9a, G9A histone methyltransferase, G9a protein, G9a like protein, G9a-like protein 1, GAT8, GLP 1, H3-K9-HMTase 3, H3-K9-HMTase 5, HLA-B-associated transcript 8, HSN1E, Histone H3-K9 methyltransferase 3, Histone H3-K9 methyltransferase 5, Histone lysine N methyltransferase H3 lysine 9 specific 5, Histone lysine N methyltransferase, H3 lysine 9 specific 3, Histone-lysine N-methyltransferase, Histone-lysine N-methyltransferase EHMT1, Histone-lysine N-methyltransferase EHMT2, KIAA1876, KMT1 C, Lysine N-methyltransferase 1C, Lysine N-methyltransferase 1D, M.HsaI, MCMT, MGC104992, Met1, MommeD2, NG 36, OCR, Ovarian cancer-related protein, Protein G9a, RP11 188C12.1, SPIN, SPIN1_HUMAN, Spindlin-1, bA188C12.1, mMmul

1 Images
Chemical Structure - UNC0638, G9 and GLP histone methyltransferase inhibitor (AB142157)
  • Chemical Structure

Lab

Chemical Structure - UNC0638, G9 and GLP histone methyltransferase inhibitor (AB142157)

2D chemical structure image of ab142157, UNC0638, G9 and GLP histone methyltransferase inhibitor

Key facts

CAS number

1255580-76-7

Purity

>98%

Form

Solid

form

Molecular weight

509.7 Da

Molecular formula

C<sub>3</sub><sub>0</sub>H<sub>4</sub><sub>7</sub>N<sub>5</sub>O<sub>2</sub>

PubChem

46224516

Nature

Synthetic

Solubility

Soluble in DMSO to 10 mM

Biochemical name

2-Cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine

Biological description

Potent, selective and reversible G9 and GLP histone methyl transferase inhibitor (IC50 values are 15 and 19 nM respectively). Maintains HSC multipotency in vitro. Cell-permeable.

Canonical smiles

CC(C)N1CCC(CC1)NC2=NC(=NC3=CC(=C(C=C32)OC)OCCCN4CCCC4)C5CCCCC5

InChi

InChI=1S/C30H47N5O2/c1-22(2)35-17-12-24(13-18-35)31-30-25-20-27(36-3)28(37-19-9-16-34-14-7-8-15-34)21-26(25)32-29(33-30)23-10-5-4-6-11-23/h20-24H,4-19H2,1-3H3,(H,31,32,33)

InChiKey

QOECJCJVIMVJGX-UHFFFAOYSA-N

IUPAC Name

2-cyclohexyl-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Refer to SDS for further information.

Product protocols

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