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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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MW 456.7 Da, Purity >99%. Pentacyclic triterpenoid. Suppresses NF-κB activation in vitro. Antitumourigenic, antiangiogenic, anti-inflammatory and proapoptotic effects.
77-52-1
> 99%
Solid
456.7 Da
C30H48O3
64945
Synthetic
11-DH, 11-beta hydroxysteroid dehydrogenase, type 1, 11-beta-HSD1, 11-beta-hydroxysteroid dehydrogenase 1, 11DH, ADR, AKR1B 1, ALDR_HUMAN, ALR2, AR, ARO, ARO1, Aldehyde reductase, Aldehyde reductase 1, Aldo-keto reductase family 1 member B1, Aldose reductase, Aromatase, Avian reticuloendotheliosis viral (v rel) oncogene homolog A, BG 37, CORTRD2, CP19A_HUMAN, CPV1, CYAR, CYP19, CYPXIX, Corticosteroid 11-beta-dehydrogenase isozyme 1, Cyp19a1, Cytochrome P-450AROM, Cytochrome P450 19A1, Cytochrome P450, family 19, subfamily A, polypeptide 1, Cytochrome P450, subfamily XIX (aromatization of androgens), DHI1_HUMAN, DNA directed DNA polymerase beta, DNA pol beta, DNA polymerase beta, DNA polymerase beta subunit, DPOLB_HUMAN, Estrogen synthase, Estrogen synthetase, G protein coupled bile acid receptor BG 37, G-protein coupled bile acid receptor 1, G-protein coupled receptor GPCR19, GPBAR 1, GPBAR_HUMAN, GPCR, GPCR 19, GPR 131, HDL, HSD 11, HSD11B, HSD11L, Hydroxysteroid (11 beta) dehydrogenase, Hydroxysteroid (11 beta) dehydrogenase 1, IMD42, Lii5 2 CTCL tumor antigen, Liver-specific organic anion transporter 1, Low Km aldose reductase, M-BAR, MGC104309, MGC125976, MGC129539, MGC131774, MGC13539, MGC1804, MGC40597, Membrane bile acid receptor, Membrane-type receptor for bile acids, Microsomal monooxygenase, NF kappa B p65delta3, NFKB3, NFkB p65, NR1F3, Nuclear factor NF-kappa-B p65 subunit, Nuclear factor kappa-B, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, OATP-2, OATP-C, OTTHUMP00000162543, OTTHUMP00000198350, OTTHUMP00000233473, OTTHUMP00000233474, OTTHUMP00000233475, OTTHUMP00000233476, OTTHUMP00000233900, P 450AROM, Pol B, Pol beta, Polymerase (DNA directed) beta, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-related orphan receptor C, RORG_HUMAN, RZR GAMMA, RZRG, Retinoic acid binding receptor gamma, Retinoid-related orphan receptor-gamma, Rorc, SDR26C1, SLC21A6, SLCO1B1, SO1B1_HUMAN, Sodium-independent organic anion-transporting polypeptide 2, Solute carrier family 21 member 6, Solute carrier organic anion transporter family member 1B1, TF65_HUMAN, TGR 5, TOR, Transcription factor NFKB3, Transcription factor p65, V rel avian reticuloendotheliosis viral oncogene homolog A, V rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B cells 3, p65, aldo-keto reductase family 1, member B1 (aldose reductase), aldr 1, flavoprotein-linked monooxygenase, hBG 37, hGPCR 19, nfkappabp65, p65, p65 NF kappaB, p65 NFkB, relA, short chain dehydrogenase/reductase family 26C, member 1, v rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (p65)), v rel reticuloendotheliosis viral oncogene homolog A (avian)
MW 456.7 Da, Purity >99%. Pentacyclic triterpenoid. Suppresses NF-κB activation in vitro. Antitumourigenic, antiangiogenic, anti-inflammatory and proapoptotic effects.
11-DH, 11-beta hydroxysteroid dehydrogenase, type 1, 11-beta-HSD1, 11-beta-hydroxysteroid dehydrogenase 1, 11DH, ADR, AKR1B 1, ALDR_HUMAN, ALR2, AR, ARO, ARO1, Aldehyde reductase, Aldehyde reductase 1, Aldo-keto reductase family 1 member B1, Aldose reductase, Aromatase, Avian reticuloendotheliosis viral (v rel) oncogene homolog A, BG 37, CORTRD2, CP19A_HUMAN, CPV1, CYAR, CYP19, CYPXIX, Corticosteroid 11-beta-dehydrogenase isozyme 1, Cyp19a1, Cytochrome P-450AROM, Cytochrome P450 19A1, Cytochrome P450, family 19, subfamily A, polypeptide 1, Cytochrome P450, subfamily XIX (aromatization of androgens), DHI1_HUMAN, DNA directed DNA polymerase beta, DNA pol beta, DNA polymerase beta, DNA polymerase beta subunit, DPOLB_HUMAN, Estrogen synthase, Estrogen synthetase, G protein coupled bile acid receptor BG 37, G-protein coupled bile acid receptor 1, G-protein coupled receptor GPCR19, GPBAR 1, GPBAR_HUMAN, GPCR, GPCR 19, GPR 131, HDL, HSD 11, HSD11B, HSD11L, Hydroxysteroid (11 beta) dehydrogenase, Hydroxysteroid (11 beta) dehydrogenase 1, IMD42, Lii5 2 CTCL tumor antigen, Liver-specific organic anion transporter 1, Low Km aldose reductase, M-BAR, MGC104309, MGC125976, MGC129539, MGC131774, MGC13539, MGC1804, MGC40597, Membrane bile acid receptor, Membrane-type receptor for bile acids, Microsomal monooxygenase, NF kappa B p65delta3, NFKB3, NFkB p65, NR1F3, Nuclear factor NF-kappa-B p65 subunit, Nuclear factor kappa-B, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, OATP-2, OATP-C, OTTHUMP00000162543, OTTHUMP00000198350, OTTHUMP00000233473, OTTHUMP00000233474, OTTHUMP00000233475, OTTHUMP00000233476, OTTHUMP00000233900, P 450AROM, Pol B, Pol beta, Polymerase (DNA directed) beta, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-related orphan receptor C, RORG_HUMAN, RZR GAMMA, RZRG, Retinoic acid binding receptor gamma, Retinoid-related orphan receptor-gamma, Rorc, SDR26C1, SLC21A6, SLCO1B1, SO1B1_HUMAN, Sodium-independent organic anion-transporting polypeptide 2, Solute carrier family 21 member 6, Solute carrier organic anion transporter family member 1B1, TF65_HUMAN, TGR 5, TOR, Transcription factor NFKB3, Transcription factor p65, V rel avian reticuloendotheliosis viral oncogene homolog A, V rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B cells 3, p65, aldo-keto reductase family 1, member B1 (aldose reductase), aldr 1, flavoprotein-linked monooxygenase, hBG 37, hGPCR 19, nfkappabp65, p65, p65 NF kappaB, p65 NFkB, relA, short chain dehydrogenase/reductase family 26C, member 1, v rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (p65)), v rel reticuloendotheliosis viral oncogene homolog A (avian)
77-52-1
> 99%
Solid
456.7 Da
C30H48O3
64945
Synthetic
One part dissolves in 88 parts methanol, 178 alcohol, (35 boiling alcohol), 140 ether, 388 chloroform, 1675 carbon disulfide. Moderately soluble in acetone. Soluble in hot glacial acetic acid and in 2% alcoholic NaOH. Insoluble in petroleum ether. In water, 1.02X10-4 mg/L at 25 °C (est).
Ursolic acid
Pentacyclic triterpenoid. Suppresses NF-κB activation in vitro. Antitumourigenic, antiangiogenic, anti-inflammatory and proapoptotic effects.
CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)O)C)C)C2C1C)C)C(=O)O
C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O)C)C)[C@@H]2[C@H]1C)C)C(=O)O
InChI=1S/C30H48O3/c1-18-10-15-30(25(32)33)17-16-28(6)20(24(30)19(18)2)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h8,18-19,21-24,31H,9-17H2,1-7H3,(H,32,33)/t18-,19+,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
WCGUUGGRBIKTOS-GPOJBZKASA-N
(1S,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
Ambient - Can Ship with Ice
-20°C
Store under desiccating conditions, The product can be stored for up to 12 months
NF-kB p65 regulates gene expression in response to stress infection and cytokines as part of the NF-kB complex. It associates within a larger complex that translocates to the nucleus to modulate transcription. DNA Polymerase beta plays an important role in DNA repair filling in single nucleotide gaps generated during repair processes. GPCR TGR5 acts as a bile acid sensor influencing bile acid homeostasis and energy metabolism. As a transcription factor ROR gamma regulates immune responses and lymphoid organogenesis. OATP1B1 acts as a transporter affecting the hepatic uptake of various endogenous compounds and drugs. Aromatase converts androgens to estrogens influencing reproductive function and sex steroid-related processes. HSD11B1 modulates local concentrations of active glucocorticoids impacting glucose metabolism. Aldose reductase reduces aldehydes to alcohols having significant roles in oxidative stress responses.
NF-kB p65 also known as RelA forms a critical component of the NF-kB transcription factor complex. This protein generally weighs about 65 kDa and localizes primarily to the cytoplasm but translocates to the nucleus during activation. DNA Polymerase beta is a small protein involved in base excision repair weighing approximately 39 kDa and found mainly in the nucleus of cells. GPCR TGR5 also referred to as GPBAR1 is a G protein-coupled receptor found in plasma membranes of various tissues including liver and intestines. ROR gamma a nuclear receptor also known as RORC weighs about 56 kDa and is generally expressed in immune cells. OATP1B1 known as SLCO1B1 is a transporter protein mainly expressed in the liver influencing drug metabolism. Aromatase or CYP19A1 is a cytochrome P450 enzyme expressed in various tissues including gonads and adipose tissue and weighs around 58 kDa. HSD11B1 is an enzyme involved in cortisol metabolism expressed primarily in adipose tissue and liver. Aldose reductase found in many tissues plays a role in the polyol pathway and weighs about 36 kDa.
NF-kB p65 participates in the NF-kB signaling pathway which is important for immune and inflammatory responses. It is related to IkB proteins which inhibit NF-kB by retaining it in the cytoplasm. DNA Polymerase beta functions in the base excision repair pathway where its activity is connected to other proteins like XRCC1 that coordinate repair complexes. GPCR TGR5 is involved in the bile acid signaling pathway working in conjunction with the FXR receptor to maintain metabolic balance. The activity of ROR gamma is pivotal within the Th17 differentiation pathway where it's linked to IL-17A production. OATP1B1 plays a role in detoxification pathways often interacting with drug-metabolizing cytochrome P450 enzymes. Aromatase is part of the steroidogenesis pathway converting androstenedione to estrone. HSD11B1 is involved in the glucocorticoid metabolism pathway impacting insulin signaling. Aldose reductase is linked to the polyol pathway associated with sorbitol accumulation during stress conditions.
NF-kB p65 connects to inflammatory diseases such as rheumatoid arthritis and certain cancers where its dysregulation leads to excessive inflammation or tumorigenesis. DNA Polymerase beta also connects to cancer where mutations or deficiencies in its function can result in genomic instability. GPCR TGR5 has implications in metabolic disorders like type 2 diabetes where it influences glucose metabolism and insulin sensitivity often interacting with DPP-4. ROR gamma's contributions to autoimmune disorders like ankylosing spondylitis are significant due to its regulation of immune cell differentiation. Mutations in OATP1B1 can result in altered drug responses and liver diseases due to impaired drug transport. Aromatase has roles in estrogen-dependent cancers such as breast cancer where its expression correlates with tumor growth. HSD11B1 relates to metabolic syndrome influencing obesity and insulin resistance often interacting with cortisone and cortisol. Aldose reductase is linked to diabetic complications particularly diabetic neuropathy and retinopathy due to its involvement in the conversion of glucose to sorbitol during hyperglycemia.
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2D chemical structure image of ab141113, Ursolic acid, Pentacyclic triterpenoid
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