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AB287091

V-9302

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(2 Publications)

MW 538.7 Da, Purity >98%. A competitive antagonist of transmembrane glutamine flux, that selectively targets the amino acid transporter ASCT2 (SLC1A5). V-9302 inhibits ASCT2-mediated glutamine uptake (IC50 = 9.6 μM) in HEK-293 cells.

Key facts

Purity

>98%

Form

Solid

form

Molecular weight

538.7 Da

Molecular formula

C<sub>3</sub><sub>4</sub>H<sub>3</sub><sub>8</sub>N<sub>2</sub>O<sub>4</sub>

PubChem

134603246

Nature

Synthetic

Solubility

>50 mg/ml in DMSO

Biochemical name

2-Amino-4-[bis[[2-[(3-methylphenyl)methoxy]phenyl]methyl]amino]butanoic acid

Biological description

A competitive antagonist of transmembrane glutamine flux, that selectively targets the amino acid transporter ASCT2 (SLC1A5). V-9302 inhibits ASCT2-mediated glutamine uptake (IC50 = 9.6 μM) in HEK-293 cells.

Canonical smiles

CC1=CC(=CC=C1)COC2=CC=CC=C2CN(CCC(C(=O)O)N)CC3=CC=CC=C3OCC4=CC=CC(=C4)C

InChi

InChI=1S/C34H38N2O4/c1-25-9-7-11-27(19-25)23-39-32-15-5-3-13-29(32)21-36(18-17-31(35)34(37)38)22-30-14-4-6-16-33(30)40-24-28-12-8-10-26(2)20-28/h3-16,19-20,31H,17-18,21-24,35H2,1-2H3,(H,37,38)

InChiKey

YGKNVAAMULVFNN-UHFFFAOYSA-N

IUPAC Name

2-amino-4-[bis[[2-[(3-methylphenyl)methoxy]phenyl]methyl]amino]butanoic acid

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called B2563 V-9302. B2563-5 is the same size as the 5 mg size of ab287091.
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark
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Product protocols

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nature medicine 24:194-202 PubMed29334372

2018

Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models.

Applications

Unspecified application

Species

Unspecified reactive species

Michael L Schulte,Allie Fu,Ping Zhao,Jun Li,Ling Geng,Shannon T Smith,Jumpei Kondo,Robert J Coffey,Marc O Johnson,Jeffrey C Rathmell,Joe T Sharick,Melissa C Skala,Jarrod A Smith,Jordan Berlin,M Kay Washington,Michael L Nickels,H Charles Manning

Bioorganic & medicinal chemistry letters 26:1044-1047 PubMed26750251

2016

2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport.

Applications

Unspecified application

Species

Unspecified reactive species

Michael L Schulte,Alexandra B Khodadadi,Madison L Cuthbertson,Jarrod A Smith,H Charles Manning
View all publications
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