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AB120745

Valproic acid, sodium salt, Histone deacetylase inhibitor

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(1 Publication)

MW 166.2 g/mol. Histone deacetylase inhibitor (IC50 = 0.4 μM for HDAC1). Increases GABA expression and activates Wnt dependent gene expression. Centrally active upon oral and intravenous administration.
2 Images
Immunocytochemistry/ Immunofluorescence - Valproic acid, sodium salt, Histone deacetylase inhibitor (AB120745)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Valproic acid, sodium salt, Histone deacetylase inhibitor (AB120745)

ab70362 staining adiponectin receptor 1 in HepG2 cells treated with valproic acid, sodium salt (ab120745), by ICC/IF. Increased cytoplasmatic staining of adiponectin receptor 1 correlates with increased concentration of valproic acid, as described in literature. The cells were incubated at 37°C for 24h in media containing different concentrations of ab120745 (valproic acid) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab70362 (5 μg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Valproic acid, sodium salt, Histone deacetylase inhibitor (AB120745)
  • Chemical Structure

Lab

Chemical Structure - Valproic acid, sodium salt, Histone deacetylase inhibitor (AB120745)

2D chemical structure image of ab120745, Valproic acid, sodium salt, Histone deacetylase inhibitor

Key facts

CAS number

1069-66-5

Form

Solid

form

Molecular weight

166.2 g/mol

Molecular formula

C<sub>8</sub>H<sub>1</sub><sub>5</sub>NaO<sub>2</sub>

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biological description

Histone deacetylase inhibitor (IC50 = 0.4 μM for HDAC1). Increases GABA expression and activates Wnt dependent gene expression. Centrally active upon oral and intravenous administration.

IUPAC Name

Sodium 2-propylpentanoate

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Burns & trauma 11:tkad032 PubMed37397510

2023

Notch4 participates in mesenchymal stem cell-induced differentiation in 3D-printed matrix and is implicated in eccrine sweat gland morphogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Yuzhen Wang,Fanliang Zhang,Bin Yao,Linhao Hou,Zhao Li,Wei Song,Yi Kong,Yaxin Tan,Xiaobing Fu,Sha Huang
View all publications
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