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AB141224

Vancomycin hydrochloride, Tricyclic glycopeptide antibiotic

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MW 1449.2 Da, Purity >95%. Tricyclic glycopeptide antibiotic. Inhibits cell wall synthesis in Gram-positive bacteria. Pharmacologically active in vivo.

View Alternative Names

ADA2A_HUMAN, ADRA2, ADRA2A, ADRA2R, ADRAR, ALBU_HUMAN, Adrenergic alpha 2A receptor, Albumin (32 AA), Albumin (AA 34), Alpha 2AAR subtype C10, Alpha-2 adrenergic receptor subtype C10, Alpha-2A adrenergic receptor, Alpha-2A adrenoceptor, Alpha-2A adrenoreceptor, Alpha-2AAR, DKFZp779N1935, GIG20, GIG42, OTTHUMP00000058849, OTTHUMP00000220436, OTTHUMP00000220438, OTTHUMP00000220439, PRO0883, PRO0903, PRO1341, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341, alpha-2-adrenergic receptor, platelet type, cell growth inhibiting protein 42, growth-inhibiting protein 20

1 Images
Chemical Structure - Vancomycin hydrochloride, Tricyclic glycopeptide antibiotic (AB141224)
  • Chemical Structure

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Chemical Structure - Vancomycin hydrochloride, Tricyclic glycopeptide antibiotic (AB141224)

2D chemical structure image of ab141224, Vancomycin hydrochloride, Tricyclic glycopeptide antibiotic

Key facts

CAS number

1404-90-6

Purity

>95%

Form

Solid

form

Molecular weight

1449.2 Da

Molecular formula

C<sub>6</sub><sub>6</sub>H<sub>7</sub><sub>5</sub>Cl<sub>2</sub>N<sub>9</sub>O<sub>2</sub><sub>4</sub>

PubChem

14969

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biochemical name

Vancomycin

Biological description

Tricyclic glycopeptide antibiotic. Inhibits cell wall synthesis in Gram-positive bacteria. Pharmacologically active in vivo.

Canonical smiles

CC1C(C(CC(O1)OC2C(C(C(OC2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)C(C(C(=O)NC(C(=O)NC5C(=O)NC7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)C(NC(=O)C(C(C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)CC(=O)N)NC(=O)C(CC(C)C)NC)O)Cl)CO)O)O)(C)N)O

Isomeric smiles

C[C@H]1[C@H]([C@@](C[C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)[C@H]([C@H](C(=O)N[C@H](C(=O)N[C@H]5C(=O)N[C@@H]7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)[C@H](NC(=O)[C@H]([C@@H](C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)CC(=O)N)NC(=O)[C@@H](CC(C)C)NC)O)Cl)CO)O)O)(C)N)O

InChi

InChI=1S/C66H75Cl2N9O24/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95)/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-/m0/s1

InChiKey

MYPYJXKWCTUITO-LYRMYLQWSA-N

IUPAC Name

(1S,2R,18R,19R,22S,25R,28R,40S)-48-[(2S,3R,4S,5S,6R)-3-[(2S,4S,5S,6S)-4-amino-5-hydroxy-4,6-dimethyloxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-22-(2-amino-2-oxoethyl)-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[[(2R)-4-methyl-2-(methylamino)pentanoyl]amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentazaoctacyclo[26.14.2.23,6.214,17.18,12.129,33.010,25.034,39]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34(39),35,37,46,49-pentadecaene-40-carboxylic acid

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Albumin alpha 2a adrenergic receptor also known as ADRA2A is a G protein-coupled receptor with a mass of approximately 50 kDa. This receptor is mainly expressed in the central nervous system including the brain and in peripheral tissues like the pancreas. It binds to catecholamines such as norepinephrine playing a role in regulating various physiological functions. The presence of glycopeptide structures suggests post-translational modifications that can affect the receptor's activity and stability.
Biological function summary

The alpha 2a adrenergic receptor is associated with inhibitory neurotransmitter release and can form part of a receptor complex influencing processes like vasoconstriction and insulin secretion. It also modulates the release of epinephrine and norepinephrine from the adrenal glands impacting blood pressure and stress responses. In pancreatic tissues this receptor's activity influences insulin release illustrating its role in glucose metabolism.

Pathways

Alpha 2a adrenergic receptor functions prominently in the sympathetic nervous system pathways and the regulation of neurotransmitter release. It interacts closely with other adrenergic receptors such as beta adrenergic receptors to maintain cardiovascular homeostasis. The signaling pathways it engages often involve G protein-mediated pathways that influence cyclic AMP levels affecting downstream cellular effects significant for both cardiovascular and metabolic homeostasis.

The alpha 2a adrenergic receptor has been connected to conditions such as hypertension and type 2 diabetes. In hypertension its role in vasoconstriction and neurotransmitter release affects vascular resistance and blood pressure regulation. Studies have noted its interaction with insulin and other metabolic hormones making it a receptor of interest in type 2 diabetes research. Dysregulation of this receptor is under investigation for its contributions to these conditions potentially opening pathways for targeted therapies.
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Product protocols

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