JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB120536

Vecuronium bromide, Competitive nicotinic acetylcholine receptor antagonist

Be the first to review this product! Submit a review

|

(4 Publications)

MW 637.74 g/mol. Competitive nicotinic acetylcholine receptor (nAChR) antagonist (IC50 = 9.9 nM). Muscle relaxant. Inhibits neural response to hypoxia.
1 Images
Chemical Structure - Vecuronium bromide, Competitive nicotinic acetylcholine receptor antagonist (AB120536)
  • Chemical Structure

Lab

Chemical Structure - Vecuronium bromide, Competitive nicotinic acetylcholine receptor antagonist (AB120536)

2D chemical structure image of ab120536, Vecuronium bromide, Competitive nicotinic acetylcholine receptor antagonist

Key facts

CAS number

50700-72-6

Form

Solid

form

Molecular weight

637.74 g/mol

Molecular formula

C<sub>3</sub><sub>4</sub>H<sub>5</sub><sub>7</sub>BrN<sub>2</sub>O<sub>4</sub>

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

Soluble in water to 25 mM

Biological description

Competitive nicotinic acetylcholine receptor (nAChR) antagonist (IC50 = 9.9 nM). Muscle relaxant. Inhibits neural response to hypoxia.

Isomeric smiles

[BR-].C[N+]1(CCCCC1)C2C[C@H]3C4CC[C@H]5C[C@H](OC(C)=O)C(CC5(C)[C@H]4CCC3(C)C2OC(C)=O)N6CCCCC6

InChi

InChI=1S/C34H57N2O4.BrH/c1-23(37)39-31-20-25-12-13-26-27(34(25,4)22-29(31)35-16-8-6-9-17-35)14-15-33(3)28(26)21-30(32(33)40-24(2)38)36(5)18-10-7-11-19-36;/h25-32H,6-22H2,1-5H3;1H/q+1;/p-1/t25-,26?,27-,28-,29?,30?,31-,32?,33?,34?;/m0./s1

InChiKey

VEPSYABRBFXYIB-HDEGTDFTSA-M

IUPAC Name

1-[(2β,3α,5α,16β,17β)-3,17-Bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl]-1-methylpiperidinium bromide

style
left-column

Complementary Products

Biochemicals

AB120003

D-AP5, NMDA glutamate site antagonist

Chemical Structure - D-AP5, NMDA glutamate site antagonist (AB120003)

  • 0
  • 0
Biochemicals

AB120009

PPADS, P2 purinergic receptor antagonist

Functional Studies - PPADS, P2 purinergic receptor antagonist (AB120009)

  • 0
  • 0
Biochemicals

AB120042

SR95531 (Gabazine), GABAA antagonist

Chemical Structure - SR95531 (Gabazine), GABAA antagonist (AB120042)

  • 0
  • 0
Biochemicals

AB120315

Picrotoxin, GABAA antagonist

Chemical Structure - Picrotoxin, GABAA antagonist (AB120315)

  • 5
  • 1
style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column

Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Food and chemical toxicology : an international jo 128:256-266 PubMed30959089

2019

Decreased levels of H3K9ac and H3K27ac in the promotor region of ovarian P450 aromatase mediated low estradiol synthesis in female offspring rats induced by prenatal nicotine exposure as well as in human granulosa cells after nicotine treatment.

Applications

Unspecified application

Species

Unspecified reactive species

Guanlan Fan,Qi Zhang,Yang Wan,Feng Lv,Yunxi Chen,Yuan Ni,Wen Zou,Wei Zhang,Hui Wang

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 123:314-325 PubMed30389584

2018

Excitotoxicity and compensatory upregulation of GAD67 in fetal rat hippocampus caused by prenatal nicotine exposure are associated with inhibition of the BDNF pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yun Pei,Zhexiao Jiao,Wanting Dong,Linguo Pei,Xia He,Hui Wang,Dan Xu

Toxicology letters 296:31-38 PubMed30036686

2018

Placental mechanism of prenatal nicotine exposure-reduced blood cholesterol levels in female fetal rats.

Applications

Unspecified application

Species

Unspecified reactive species

Guohui Zhang,Jin Zhou,Wen Huang,Luting Yu,Yuanzhen Zhang,Hui Wang

Toxicology and applied pharmacology 344:1-12 PubMed29486207

2018

nAChRs-ERK1/2-Egr-1 signaling participates in the developmental toxicity of nicotine by epigenetically down-regulating placental 11β-HSD2.

Applications

Unspecified application

Species

Unspecified reactive species

Jin Zhou,Fulin Liu,Luting Yu,Dan Xu,Bin Li,Guohui Zhang,Wen Huang,Lu Li,Yuanzhen Zhang,Wei Zhang,Hui Wang
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com