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AB120715

Venlafaxine hydrochloride, Serotonin-norepinephrine reuptake inhibitor

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MW 313.87 g/mol, Purity >99%. Serotonin-norepinephrine reuptake inhibitor. Ki values are 82 and 2480 nM for SERT and NET, respectively. Displays 30-fold higher affinity for SERT than NET in vitro. Antidepressant.
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Functional Studies - Venlafaxine hydrochloride, Serotonin-norepinephrine reuptake inhibitor (AB120715)
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Functional Studies - Venlafaxine hydrochloride, Serotonin-norepinephrine reuptake inhibitor (AB120715)

ab18207 staining beta III tubulin in PC-12 cells treated with venlafaxine hydrochloride (ab120715), by ICC/IF. Increase in the number and length of neurites (stained with beta III tubulin) correlates with increased concentration of venlafaxine hydrochloride, as described in literature.
The NGF treated cells were incubated at 37°C for 6 hour in media containing different concentrations of ab120715 (venlafaxine hydrochloride) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab18207 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.

Chemical Structure - Venlafaxine hydrochloride, Serotonin-norepinephrine reuptake inhibitor (AB120715)
  • Chemical Structure

Lab

Chemical Structure - Venlafaxine hydrochloride, Serotonin-norepinephrine reuptake inhibitor (AB120715)

2D chemical structure image of ab120715, Venlafaxine hydrochloride, Serotonin-norepinephrine reuptake inhibitor

Key facts

CAS number

99300-78-4

Purity

>99%

Form

Solid

form

Molecular weight

313.87 g/mol

Molecular formula

C<sub>1</sub><sub>7</sub>H<sub>2</sub><sub>7</sub>NO<sub>2</sub>.HCl

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in DMSO to 50 mM

Biological description

Serotonin-norepinephrine reuptake inhibitor. Ki values are 82 and 2480 nM for SERT and NET, respectively. Displays 30-fold higher affinity for SERT than NET in vitro. Antidepressant.

IUPAC Name

1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride

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Product details

This product is reported to be light sensitive
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Product protocols

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