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AB146680

Verapamil hydrochloride (mM/ml), L-type Ca2+ channel blocker

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(2 Publications)

MW 491.1 Da, Purity >99%. L-type Ca2+ channel blocker. Antiarrhythmic in vivo. Soluble in 1 ml water to give specified mM/ml concentration.

View Alternative Names

1,8-cineole 2-exo-monooxygenase, ABC member 16, MDR/TAP subfamily, ABC16, ABCB1, ABCBB_HUMAN, ACLS, AI838772, AIS, ANDR_HUMAN, AP-1, AR, AR8, ATP binding cassette sub family B (MDR/TAP) member 11, ATP-binding cassette sub-family B member 11, AW493413, Activator protein 1, Albendazole monooxygenase, Albendazole sulfoxidase, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease), Atherosclerosis, susceptibility to, included, BRIC2, BXR, Bile salt export pump, Bsep, CP33, CP34, CP3A4_HUMAN, CYP3, CYP3A, CYP3A3, CYP3A4, CYPIIIA3, CYPIIIA4, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450-PCN1, DHTR, DKFZp686N23123, DNA binding protein, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), ER, ER-alpha, ER-beta, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESRA, ESRL 1, ESRR A, ESTR B, Eag-related protein 1, Enhancer Binding Protein AP1, Era, Erb, Erb2, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta 4, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen resistance, included, Estrogen-related receptor alpha, Estrra, Ether a go go related potassium channel protein, Ether-a-go-go-related gene potassium channel 1, Ether-a-go-go-related protein 1, FLJ11090, GCPS, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI family zinc finger 3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3FL, GLI3_HUMAN, Glioma associated oncogene family zinc finger 3, Glucocorticoid inducible P450, H-ERG, HDL cholesterol, augmented response of, to hormone replacement, included, HLP, HUMARA, HYSP1, IMD42, JUN protein, JUNC, JUN_HUMAN, Jun Activation Domain Binding Protein, Jun oncogene, Jun proto oncogene, KCNH2_HUMAN, KD, Kennedy disease (KD), Kv11.1, LQT 2, MGC104252, MGC112732, MGC126680, MGC129539, Myocardial infarction, susceptibility to, included, NF 25, NR1F3, NR1I2_HUMAN, NR3A1, NR3A2, NR3B1, NR3C4, Nifedipine oxidase, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, Nuclear receptor subfamily 3 group B member 1, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), ONR 1, OTTHUMP00000017718, OTTHUMP00000017719, OTTHUMP00000215173, OTTHUMP00000215174, OTTHUMP00000215175, Oncogene GLI3, Oncogene JUN, Orphan nuclear receptor PAR 1, Orphan nuclear receptor PXR, P450 III steroid inducible, P450 PCN1, P450, family III, P450C3, PAP A, PAPB, PAR, PAR q, PFIC 2, PGY4, PPD IV, PRR, Potassium channel HERG, Potassium voltage gated channel subfamily H (eag related) member 2, Potassium voltage-gated channel subfamily H member 2, Pregnane X receptor, Proto-oncogene c-jun, Quinine 3-monooxygenase, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-related orphan receptor C, RNESTROR, RORG_HUMAN, RP24-311F12.2, RZR GAMMA, RZRG, Retinoic acid binding receptor gamma, Retinoid-related orphan receptor-gamma, Rorc, SBMA, SCAN1, SMAX1, SQT1, SXR, Sister of P glycoprotein, Spgp, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), Steroid and xenobiotic receptor, Steroid hormone receptor ERR1, TFM, TOR, TYDP, TYDP1_HUMAN, Taurochenodeoxycholate 6-alpha-hydroxylase, Testicular Feminization (TFM), Transcription factor AP-1, Transcriptional activator GLI3, Transcriptional repressor GLI3R, Tyr-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, V jun sarcoma virus 17 oncogene homolog, V jun sarcoma virus 17 oncogene homolog (avian), V-jun avian sarcoma virus 17 oncogene homolog, Voltage gated potassium channel, subfamily H, member 2, Voltage-gated potassium channel subunit Kv11.1, Zinc finger protein GLI 3, androgen receptor splice variant 4b, cJun, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, eag homolog, estrogen receptor related receptor alpha, hERG-1, hERR1, p39, pregnane X nuclear receptor variant 2, progressive familial intrahepatic cholestasis 2

Key facts

CAS number

152-11-4

Purity

>99%

Form

Solid

form

Molecular weight

491.1 Da

Molecular formula

C<sub>2</sub><sub>7</sub>H<sub>3</sub><sub>9</sub>ClN<sub>2</sub>O<sub>4</sub>

PubChem

62969

Nature

Synthetic

Biochemical name

Verapamil hydrochloride

Biological description

L-type Ca2+ channel blocker. Antiarrhythmic in vivo. Soluble in 1 ml water to give specified mM/ml concentration.

Canonical smiles

CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl

InChi

InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H

InChiKey

DOQPXTMNIUCOSY-UHFFFAOYSA-N

IUPAC Name

2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile;hydrochloride

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months

Product protocols

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nature biomedical engineering 5:815-829 PubMed33941899

2021

A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics.

Applications

Unspecified application

Species

Unspecified reactive species

Longlong Si,Haiqing Bai,Melissa Rodas,Wuji Cao,Crystal Yuri Oh,Amanda Jiang,Rasmus Moller,Daisy Hoagland,Kohei Oishi,Shu Horiuchi,Skyler Uhl,Daniel Blanco-Melo,Randy A Albrecht,Wen-Chun Liu,Tristan Jordan,Benjamin E Nilsson-Payant,Ilona Golynker,Justin Frere,James Logue,Robert Haupt,Marisa McGrath,Stuart Weston,Tian Zhang,Roberto Plebani,Mercy Soong,Atiq Nurani,Seong Min Kim,Danni Y Zhu,Kambez H Benam,Girija Goyal,Sarah E Gilpin,Rachelle Prantil-Baun,Steven P Gygi,Rani K Powers,Kenneth E Carlson,Matthew Frieman,Benjamin R tenOever,Donald E Ingber

Scientific reports 6:39449 PubMed27995976

2016

In vivo MEMRI characterization of brain metastases using a 3D Look-Locker T1-mapping sequence.

Applications

Unspecified application

Species

Unspecified reactive species

Charles R Castets,Néha Koonjoo,Andreea Hertanu,Pierre Voisin,Jean-Michel Franconi,Sylvain Miraux,Emeline J Ribot
View all publications

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