Veratridine, Na+ channel opener

Key facts

CAS number

71-62-5

Purity

>97%

Form

Solid

form

Source

Liliaceae sp.

Molecular weight

673.8 Da

Molecular formula

C₃₆H₅₁NO₁₁

PubChem

6610253

Nature

Native

Solubility

Soluble in ethanol to 100 mM

Biochemical name

Veratridine, >=90% (HPLC), powder

Biological description

Alkaloid toxin found in *Liliaceae* plants. Causes persistent opening of the voltage-gated Na+ channel and reduces its single-channel conductance. Channel opener.

Canonical smiles

CC1CCC2C(C3(C(CC4(C5CCC6C7(C5(CC4(C3CN2C1)O)OC6(C(CC7)OC(=O)C8=CC(=C(C=C8)OC)OC)O)C)O)O)O)(C)O

Isomeric smiles

CC1CCC2[C@@]([C@]3([C@H](C[C@]4(C5CCC6[C@]7([C@]5(C[C@]4(C3CN2C1)O)O[C@@]6(C(CC7)OC(=O)C8=CC(=C(C=C8)OC)OC)O)C)O)O)O)(C)O

InChi

InChI=1S/C36H51NO11/c1-19-6-11-26-31(3,40)35(43)25(17-37(26)16-19)33(42)18-34-24(32(33,41)15-27(35)38)10-9-23-30(34,2)13-12-28(36(23,44)48-34)47-29(39)20-7-8-21(45-4)22(14-20)46-5/h7-8,14,19,23-28,38,40-44H,6,9-13,15-18H2,1-5H3/t19?,23?,24?,25?,26?,27-,28?,30-,31+,32+,33+,34+,35-,36-/m0/s1

InChiKey

FVECELJHCSPHKY-FCSYLLAHSA-N

IUPAC Name

[(1R,10R,11S,12S,14R,19S,23S,25R)-1,10,11,12,14,23-hexahydroxy-6,10,19-trimethyl-24-oxa-4-azaheptacyclo[12.12.0.02,11.04,9.015,25.018,23.019,25]hexacosan-22-yl] 3,4-dimethoxybenzoate