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MW 205.21 Da, Purity >98%. Immunomodulatory agent. TLR4 inhibitor. TLR4 and TLR 2/6 signaling pathway modulator. Inhibits inflammatory antigen presentation. Inhibits IL1-β, IL-10, IFN-γ and TNF-α secretion. Shows anti-inflammatory effects in vivo. Orally active.

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Images

Chemical Structure - VGX-1027 (Git-27), TLR4 inhibitior (AB145857), expandable thumbnail

Key facts

CAS number
6501-72-0
Purity
> 98%
Form
Solid
Molecular weight
205.21 Da
Molecular formula
C11H11NO3
PubChem identifier
10798271
Nature
Synthetic

Target data

Recommended products

MW 205.21 Da, Purity >98%. Immunomodulatory agent. TLR4 inhibitor. TLR4 and TLR 2/6 signaling pathway modulator. Inhibits inflammatory antigen presentation. Inhibits IL1-β, IL-10, IFN-γ and TNF-α secretion. Shows anti-inflammatory effects in vivo. Orally active.

Key facts

Purity
> 98%
PubChem identifier
10798271
Solubility

Soluble in ethanol to 50 mM.

Soluble in DMSO to 25 mM.

Biochemical name
4,5-Dihydro-3-phenyl-5-isoxazoleacetic acid
Biological description

Immunomodulatory agent. TLR4 inhibitor. TLR4 and TLR 2/6 signaling pathway modulator. Inhibits inflammatory antigen presentation. Inhibits IL1-β, IL-10, IFN-γ and TNF-α secretion. Shows anti-inflammatory effects in vivo. Orally active.

Canonical SMILES
C1C(ON=C1C2=CC=CC=C2)CC(=O)O
InChI
InChI=1S/C11H11NO3/c13-11(14)7-9-6-10(12-15-9)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H,13,14)
InChIKey
MUFJHYRCIHHATF-UHFFFAOYSA-N
IUPAC name
2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • Chemical Structure - VGX-1027 (Git-27), TLR4 inhibitior (ab145857), expandable thumbnail

    Chemical Structure - VGX-1027 (Git-27), TLR4 inhibitior (ab145857)

    2D chemical structure image of ab145857, VGX-1027 (Git-27), TLR4 inhibitior

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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