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AB145857

VGX-1027 (Git-27), TLR4 inhibitor

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MW 205.21 Da, Purity >98%. Immunomodulatory agent. TLR4 inhibitor. TLR4 and TLR 2/6 signaling pathway modulator. Inhibits inflammatory antigen presentation. Inhibits IL1-β, IL-10, IFN-γ and TNF-α secretion. Shows anti-inflammatory effects in vivo. Orally active.
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Chemical Structure - VGX-1027 (Git-27), TLR4 inhibitor (AB145857)
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Chemical Structure - VGX-1027 (Git-27), TLR4 inhibitor (AB145857)

2D chemical structure image of ab145857, VGX-1027 (Git-27), TLR4 inhibitior

Key facts

CAS number

6501-72-0

Purity

>98%

Form

Solid

form

Molecular weight

205.21 Da

Molecular formula

C<sub>1</sub><sub>1</sub>H<sub>1</sub><sub>1</sub>NO<sub>3</sub>

PubChem

10798271

Nature

Synthetic

Solubility

Soluble in ethanol to 50 mM

Soluble in DMSO to 25 mM

Biochemical name

4,5-Dihydro-3-phenyl-5-isoxazoleacetic acid

Biological description

Immunomodulatory agent. TLR4 inhibitor. TLR4 and TLR 2/6 signaling pathway modulator. Inhibits inflammatory antigen presentation. Inhibits IL1-β, IL-10, IFN-γ and TNF-α secretion. Shows anti-inflammatory effects in vivo. Orally active.

Canonical smiles

C1C(ON=C1C2=CC=CC=C2)CC(=O)O

InChi

InChI=1S/C11H11NO3/c13-11(14)7-9-6-10(12-15-9)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H,13,14)

InChiKey

MUFJHYRCIHHATF-UHFFFAOYSA-N

IUPAC Name

2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Primary Antibodies

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Biochemicals

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TLR2-IN-C29

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