JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB230370

VH298, VHL inhibitor

Be the first to review this product! Submit a review

|

(2 Publications)

MW 523.6 Da, Purity >98%. VH298 is a cell permeable compound that binds tightly to VHL (KD = 80- 90 nM in in vitro binding assays) leading to cellular accumulation of HIF1-α. VH298 selectively stabilizes hydroxylated HIF1-α and induces HIF-dependent transcription.

View Alternative Names

ELOB_HUMAN, ELOC_HUMAN, Elongin 15 kDa subunit, Elongin 18 kDa subunit, Elongin binding protein, Elongin-B, Elongin-C, G7 protein, HRCA 1, Protein G7, RCA 1, RNA polymerase II transcription factor SIII p18 subunit, RNA polymerase II transcription factor SIII subunit B, RNA polymerase II transcription factor SIII subunit C, SIII, SIII p15, SIII p18, TCEB 1, TCEB 2, Transcription elongation factor B (SIII) polypeptide 1, Transcription elongation factor B (SIII) polypeptide 2, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, VHL 1, VHLH, VHL_HUMAN, Von Hippel Lindau, Von Hippel Lindau tumor suppressor, E3 ubiquitin protein ligase, Von Hippel-Lindau disease tumor suppressor, pVHL, von Hippel Lindau syndrome, von Hippel Lindau tumor suppressor

1 Images
Chemical Structure - VH298, VHL inhibitor (AB230370)
  • Chemical Structure

Lab

Chemical Structure - VH298, VHL inhibitor (AB230370)

2D chemical structure image of ab230370, VH298, VHL inhibitor

Key facts

CAS number

2097381-85-4

Purity

>98%

Form

Solid

form

Molecular weight

523.6 Da

Molecular formula

C<sub>2</sub><sub>7</sub>H<sub>3</sub><sub>3</sub>N<sub>5</sub>O<sub>4</sub>S

PubChem

122199236

Nature

Synthetic

Solubility

100 mM in DMSO

100mM in ethanol

Biochemical name

(2S,4R)-1-((S)-2-(1-cyanocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Biological description

VH298 is a cell permeable compound that binds tightly to VHL (KD = 80- 90 nM in in vitro binding assays) leading to cellular accumulation of HIF1-α. VH298 selectively stabilizes hydroxylated HIF1-α and induces HIF-dependent transcription.

Canonical smiles

CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)C4(CC4)C#N)O

Isomeric smiles

CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)C4(CC4)C#N)O

InChi

InChI=1S/C27H33N5O4S/c1-16-21(37-15-30-16)18-7-5-17(6-8-18)12-29-23(34)20-11-19(33)13-32(20)24(35)22(26(2,3)4)31-25(36)27(14-28)9-10-27/h5-8,15,19-20,22,33H,9-13H2,1-4H3,(H,29,34)(H,31,36)/t19-,20+,22-/m1/s1

InChiKey

NDVQUNZCNAMROD-RZUBCFFCSA-N

IUPAC Name

(2S,4R)-1-[(2S)-2-[(1-cyanocyclopropanecarbonyl)amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cell death and differentiation 32:1473-1483 PubMed40000790

2025

Chromosomal 3p loss and 8q gain drive vasculogenic mimicry via HIF-2α and VE-cadherin activation in uveal melanoma.

Applications

Unspecified application

Species

Unspecified reactive species

Daniel Delgado-Bellido,Antonio Chacon-Barrado,Joaquin Olmedo-Pelayo,Carmen Jordán Perez,Paula Gilabert-Prieto,Juan Díaz-Martin,Angel Garcia-Diaz,F J Oliver,Enrique de Álava

Cell 179:1144-1159.e15 PubMed31708126

2019

Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Wang,I-Ling Chiang,Takahiro E Ohara,Satoru Fujii,Jiye Cheng,Brian D Muegge,Aaron Ver Heul,Nathan D Han,Qiuhe Lu,Shanshan Xiong,Feidi Chen,Chin-Wen Lai,Hana Janova,Renee Wu,Charles E Whitehurst,Kelli L VanDussen,Ta-Chiang Liu,Jeffrey I Gordon,L David Sibley,Thaddeus S Stappenbeck
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB48506

Anti-4 Hydroxynonenal antibody [HNEJ-2]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-4 Hydroxynonenal antibody [HNEJ-2] (AB48506)

  • 4
  • 10
Biochemicals

AB230371

Mz1, selectively degrades BRD4

Chemical Structure - Mz1, selectively degrades BRD4 (AB230371)

  • 0
  • 0
Primary Antibodies

AB80592

Anti-Ku80 antibody [EPR3468]

RabMAb|Recombinant

Western blot - Anti-Ku80 antibody [EPR3468] (AB80592)

  • 0
  • 0
Primary Antibodies

AB128874

Anti-Brd4 antibody [EPR5150(2)]

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Brd4 antibody [EPR5150(2)] (AB128874)

  • 5
  • 18

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com