MW 129.16 Da, Purity >98%. Irreversible inhibitor of GABA transaminase (GABA-T). Increases GABA concentrations in the brain. Anticonvulsant and induces neuronal plasticity in mouse models.
Also available in simple stock solutions (ab146721) - add 1 ml of water to get an exact, ready-to-use concentration.
68506-86-5
> 98%
Solid
129.16 Da
C6H11NO2
5665
Synthetic
(S)-3-amino-2-methylpropionate transaminase, 4 aminobutyrate aminotransferase, mitochondrial, 4-aminobutyrate aminotransferase, ABAT, FLJ17813, FLJ30272, GABA aminotransferase, GABA transaminase, GABA transferase, GABA-AT, GABA-T, GABT_HUMAN, Gamma-amino-N-butyrate transaminase, L-AIBAT, NPD009, hCG1984265, mitochondrial
MW 129.16 Da, Purity >98%. Irreversible inhibitor of GABA transaminase (GABA-T). Increases GABA concentrations in the brain. Anticonvulsant and induces neuronal plasticity in mouse models.
Also available in simple stock solutions (ab146721) - add 1 ml of water to get an exact, ready-to-use concentration.
68506-86-5
> 98%
Solid
129.16 Da
C6H11NO2
5665
Synthetic
Soluble in water to 100 mM.
Vigabatrin
Irreversible inhibitor of GABA transaminase (GABA-T). Increases GABA concentrations in the brain. Anticonvulsant and induces neuronal plasticity in mouse models.
Also available in simple stock solutions (ab146721) - add 1 ml of water to get an exact, ready-to-use concentration.
C=CC(CCC(=O)O)N
InChI=1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9)
PJDFLNIOAUIZSL-UHFFFAOYSA-N
4-aminohex-5-enoic acid
Ambient - Can Ship with Ice
+4°C
+4°C
Store under desiccating conditions, The product can be stored for up to 12 months
This supplementary information is collated from multiple sources and compiled automatically.
ABAT also known as GABA transaminase (GABA-T) is an enzyme involved in the catabolism of the neurotransmitter gamma-aminobutyric acid (GABA). This enzyme catalyzes the conversion of GABA to succinic semialdehyde an important step in the GABA degradation pathway. GABA-T has a molecular mass of approximately 56 kDa. Its expression primarily occurs in the brain kidney and liver where it regulates GABA levels influencing neurological functions.
ABAT plays a critical role in maintaining GABA homeostasis in the central nervous system. The protein functions as a homodimer forming a complex that effectively binds to its substrate. It modulates the inhibitory effects mediated by GABA in neuronal signaling. This regulation is essential for processes such as synaptic transmission and plasticity impacting a range of neurological activities.
ABAT is integral to the GABAergic neurotransmission pathway which balances excitatory and inhibitory signals in the brain. It operates in conjunction with glutamate decarboxylase another enzyme playing an important role in GABA synthesis. Together they maintain the dynamic equilibrium between GABA production and breakdown. Additionally the enzyme interacts with proteins that contribute to the tricarboxylic acid cycle linking neurotransmitter metabolism to energy production.
ABAT is associated with several neurological conditions including epilepsy and schizophrenia. Impaired function or expression of ABAT can lead to altered GABA levels contributing to the pathophysiology of these disorders. The enzyme also connects with GABA receptor subtypes which are targets for therapeutic interventions aimed at modulating GABAergic activity to address these conditions.
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2D chemical structure image of ab120310, Vigabatrin, Irreversible GABA transaminase inhibitor
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