Skip to main content

MW 129.16 Da, Purity >98%. Irreversible inhibitor of GABA transaminase (GABA-T). Increases GABA concentrations in the brain. Anticonvulsant and induces neuronal plasticity in mouse models.

Also available in simple stock solutions (ab146721) - add 1 ml of water to get an exact, ready-to-use concentration.

Be the first to review this product! Submit a review

Images

Chemical Structure - Vigabatrin, Irreversible GABA transaminase inhibitor (AB120310), expandable thumbnail

Publications

Key facts

CAS number

68506-86-5

Purity

> 98%

Form

Solid

Molecular weight

129.16 Da

Molecular formula

C6H11NO2

PubChem identifier

5665

Nature

Synthetic

Alternative names

Recommended products

MW 129.16 Da, Purity >98%. Irreversible inhibitor of GABA transaminase (GABA-T). Increases GABA concentrations in the brain. Anticonvulsant and induces neuronal plasticity in mouse models.

Also available in simple stock solutions (ab146721) - add 1 ml of water to get an exact, ready-to-use concentration.

Key facts

Purity

> 98%

PubChem identifier

5665

Solubility

Soluble in water to 100 mM.

Biochemical name

Vigabatrin

Biological description

Irreversible inhibitor of GABA transaminase (GABA-T). Increases GABA concentrations in the brain. Anticonvulsant and induces neuronal plasticity in mouse models.

Also available in simple stock solutions (ab146721) - add 1 ml of water to get an exact, ready-to-use concentration.

Canonical SMILES

C=CC(CCC(=O)O)N

InChI

InChI=1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9)

InChIKey

PJDFLNIOAUIZSL-UHFFFAOYSA-N

IUPAC name

4-aminohex-5-enoic acid

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Storage information

Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ABAT also known as GABA transaminase (GABA-T) is an enzyme involved in the catabolism of the neurotransmitter gamma-aminobutyric acid (GABA). This enzyme catalyzes the conversion of GABA to succinic semialdehyde an important step in the GABA degradation pathway. GABA-T has a molecular mass of approximately 56 kDa. Its expression primarily occurs in the brain kidney and liver where it regulates GABA levels influencing neurological functions.

Biological function summary

ABAT plays a critical role in maintaining GABA homeostasis in the central nervous system. The protein functions as a homodimer forming a complex that effectively binds to its substrate. It modulates the inhibitory effects mediated by GABA in neuronal signaling. This regulation is essential for processes such as synaptic transmission and plasticity impacting a range of neurological activities.

Pathways

ABAT is integral to the GABAergic neurotransmission pathway which balances excitatory and inhibitory signals in the brain. It operates in conjunction with glutamate decarboxylase another enzyme playing an important role in GABA synthesis. Together they maintain the dynamic equilibrium between GABA production and breakdown. Additionally the enzyme interacts with proteins that contribute to the tricarboxylic acid cycle linking neurotransmitter metabolism to energy production.

Associated diseases and disorders

ABAT is associated with several neurological conditions including epilepsy and schizophrenia. Impaired function or expression of ABAT can lead to altered GABA levels contributing to the pathophysiology of these disorders. The enzyme also connects with GABA receptor subtypes which are targets for therapeutic interventions aimed at modulating GABAergic activity to address these conditions.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • Chemical Structure - Vigabatrin, Irreversible GABA transaminase inhibitor (ab120310), expandable thumbnail

    Chemical Structure - Vigabatrin, Irreversible GABA transaminase inhibitor (ab120310)

    2D chemical structure image of ab120310, Vigabatrin, Irreversible GABA transaminase inhibitor

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com