JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB141475

Vinblastine sulfate, Microtubule dynamics inhibitor

Be the first to review this product! Submit a review

|

(0 Publication)

MW 909.1 Da, Purity >95%. Potent microtubule dynamics inhibitor. Inhibits tubulin addition (Ki = 0.18 μM). Suppresses mitotic spindle formation. Induces apoptosis. Vincristine (ab120226) analog. Potent antiproliferative effects (IC50 = 1 nM). Antitumor effects in vivo. .

View Alternative Names

2810484G07Rik, ALS22, Alpha tubulin, Alpha tubulin isotype M alpha 6, Alpha-tubulin 1, Alpha-tubulin 3, Alpha-tubulin 3E, Alpha-tubulin 6, Alpha-tubulin ubiquitous, B ALPHA 1, Beta 4 tubulin, Beta 5 tubulin, Beta tubulin 1, class VI, Beta-tubulin, Beta2, CDCBM, CDCBM1, CDCBM5, CDCBM6, CFEOM3, CFEOM3A, Class I beta tubulin, Class II beta tubulin isotype, Class IVb beta tubulin, Class VI beta tubulin, Class VIII beta tubulin, DKFZp566F223, Dystonia 4 torsion (autosomal dominant), FEOM3, FLJ25113, FLJ98847, H2 ALPHA, HSA10p15 beta tubulin 4Q, HsT1601, Hum a tub1, Hum a tub2, K-ALPHA-1, LIS3, M(beta)1, M(beta)2, M(beta)3, M(beta)6, M40, MC1-R, MGC117247, MGC16435, MGC171407, MGC55332, MGC8685, M[a]6, Neuron specific beta III Tubulin, Neuron-specific class III beta-tubulin, OK/SW-cl.56, OTTHUMP00000015956, OTTHUMP00000015964, QccE-11995, QccE-15186, RP11-631M21.2, TBA1A_HUMAN, TBA1B_HUMAN, TBA1C_HUMAN, TBA3E_HUMAN, TBA4A_HUMAN, TBB1_HUMAN, TBB2A_HUMAN, TBB2B_HUMAN, TBB3_HUMAN, TBB4B_HUMAN, TBB4_HUMAN, TBB5_HUMAN, TBB6_HUMAN, TBB8_HUMAN, TUBA1, TUBA1A, TUBA1B, TUBA3, TUBA3E, TUBA4A, TUBA6, TUBB, TUBB 1, TUBB 2, TUBB 2A, TUBB 2C, TUBB 4, TUBB PARALOG, TUBB-5, TUBB2B, TUBB4A, TUBB6, TUBB8, Testis-specific alpha-tubulin, Tubb 3, Tubb4b, Tubulin 5 beta, Tubulin B-alpha-1, Tubulin H2-alpha, Tubulin K-alpha-1, Tubulin alpha, Tubulin alpha 1a, Tubulin alpha 3, Tubulin alpha brain specific, Tubulin alpha-1 chain, Tubulin alpha-1A chain, Tubulin alpha-1B chain, Tubulin alpha-1C chain, Tubulin alpha-3 chain, Tubulin alpha-3E chain, Tubulin alpha-4A chain, Tubulin alpha-6 chain, Tubulin alpha-ubiquitous chain, Tubulin beta, Tubulin beta 1 class VI, Tubulin beta 1b, Tubulin beta 2, Tubulin beta 2A, Tubulin beta 2A class IIa, Tubulin beta 2B, Tubulin beta 2B class IIb, Tubulin beta 2C, Tubulin beta 3, Tubulin beta 4, Tubulin beta 4A class IVa, Tubulin beta 5, Tubulin beta 8, Tubulin beta 8 class VIII, Tubulin beta IV, Tubulin beta chain, Tubulin beta class I, Tubulin beta polypeptide, Tubulin beta polypeptide 2, Tubulin beta polypeptide paralog, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-2A chain, Tubulin beta-2B chain, Tubulin beta-2C chain, Tubulin beta-3 chain, Tubulin beta-4 chain, Tubulin beta-4B chain, Tubulin beta-5 chain, Tubulin beta-6, Tubulin beta-6 chain, Tubulin beta-8 chain, Tubulin beta-III, Tubulin, alpha 1 (testis specific), Tubulin, alpha 4a, Tubulin, alpha, testis-specific, Tubulin, alpha-1, Tubulin, beta 1, Tubulin, beta, class IVB, Tubulin, beta-4B, bA408E5.3, bA506K6.1, bA631M21.2, bcm948, beta 1 tubulin, beta 2 tubulin, beta 3 tubulin, beta 5, beta Ib tubulin, beta four tubulin, beta-4, class IIa beta-tubulin, class IIb beta-tubulin, class V beta-tubulin, dJ40E16.7, dJ543J19.4, fd02b12, tuba1l, tubulin alpha 1b, tubulin alpha 6, tubulin beta 6 class V, tubulin beta MGC4083, tubulin beta class V, tubulin beta-6 chain-like, tubulin, alpha 1, like, tubulin, alpha 1c, tubulin, alpha 3e, tubulin, alpha, ubiquitous, tubulin, beta 4B class IVb, tubulin, beta, class IIA, tuj 1, wu:fd02b12, zgc:55461

1 Images
Chemical Structure - Vinblastine sulfate, Microtubule dynamics inhibitor (AB141475)
  • Chemical Structure

Lab

Chemical Structure - Vinblastine sulfate, Microtubule dynamics inhibitor (AB141475)

2D chemical structure image of ab141475, Vinblastine sulfate, Microtubule dynamics inhibitor

Key facts

CAS number

143-67-9

Purity

>95%

Form

Solid

form

Molecular weight

909.1 Da

Molecular formula

C<sub>4</sub><sub>6</sub>H<sub>5</sub><sub>8</sub>N<sub>4</sub>O<sub>9</sub>.H<sub>2</sub>O<sub>4</sub>S

PubChem

241902

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biochemical name

Vincaleukoblastine sulfate

Biological description

Potent microtubule dynamics inhibitor. Inhibits tubulin addition (Ki = 0.18 μM). Suppresses mitotic spindle formation. Induces apoptosis. Vincristine (ab120226) analog. Potent antiproliferative effects (IC50 = 1 nM). Antitumor effects in vivo.

Canonical smiles

CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O

Isomeric smiles

CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O

InChi

InChI=1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1

InChiKey

KDQAABAKXDWYSZ-JKDPCDLQSA-N

IUPAC Name

methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate;sulfuric acid

Product details

This product is manufactured by BioVision, an Abcam company and was previously called 1959 Vinblastine Sulfate. 1959-25 is the same size as the 25 mg size of ab141475.

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tubulin is a family of globular proteins and essential components of microtubules which play an important role in maintaining cellular structure and facilitating intracellular transport. The beta-tubulins including beta III beta I beta IV beta II and alpha tubulin have molecular masses ranging around 50 kDa. Tubulin proteins are expressed in various tissues with beta-tubulin III expressing highly in neurons. Alternate names for tubulin include TUBA1C TUBA1A TUBB2A TUBB8 TUBB2B TUBB6 and TUBA3E. These proteins contribute to the assembly of microtubules influencing their dynamics and stability.
Biological function summary

Tubulin proteins form part of the microtubule complex which is fundamental to cellular processes such as mitosis and intracellular transport. These proteins influence microtubule dynamics important in chromosome segregation and signaling pathways involving cell movement and division. Tubulin interacts with various chemical structures such as vinblastine which affects microtubule polymerization. The dynamic instability of microtubules is important for their role in cell cycle progression and neuronal development.

Pathways

Tubulin family proteins participate in significant pathways like the mitotic spindle assembly and axonal transport. These pathways have implications in the regulation of cell cycle and neuronal functioning. Related proteins within these pathways include kinesins and dyneins which are motor proteins that transport cellular cargo along microtubules. The regulation of these pathways ensures proper cell division and neuronal signaling which are essential for organismal development and homeostasis.

Tubulin is linked with neurodegenerative diseases such as Alzheimer's disease and cancer. Tubulin dysfunction can impact microtubule assembly leading to errors in chromosome segregation and neuronal damage. Proteins connected to tubulin dysfunction include tau protein in Alzheimer's disease which aggregates and disturbs microtubule stability. In cancer aberrant tubulin activity may influence the effectiveness of chemotherapeutic agents targeting microtubule dynamics potentially impacting treatment outcomes.

Product protocols

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com