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AB142167

Vinorelbine tartrate (Navelbine), mitotic microtubule antagonist

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MW 270.3 Da, Purity >98%. Selective mitotic microtubule antagonist. Inhibits multiple human tumor cell lines (IC50 = 1.25 nM in HeLa cells). Blocks metaphase/anaphase transition (IC50 = 3.8 nM). Active in vivo. Orally active. Shows antimitotic and antitumor activity.
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Chemical Structure - Vinorelbine tartrate (Navelbine), mitotic microtubule antagonist (AB142167)
  • Chemical Structure

Lab

Chemical Structure - Vinorelbine tartrate (Navelbine), mitotic microtubule antagonist (AB142167)

2D chemical structure image of ab142167, Vinorelbine tartrate (Navelbine), mitotic microtubule antagonist

Key facts

Purity

>98%

Form

Solid

form

Molecular weight

270.3 Da

Molecular formula

C<sub>1</sub><sub>2</sub>H<sub>1</sub><sub>4</sub>O<sub>5</sub>S

PubChem

607791

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in DMSO to 100 mM

Biochemical name

o-Carbethoxy-5-methylthio vanillin

Biological description

Selective mitotic microtubule antagonist. Inhibits multiple human tumor cell lines (IC50 = 1.25 nM in HeLa cells). Blocks metaphase/anaphase transition (IC50 = 3.8 nM). Active in vivo. Orally active. Shows antimitotic and antitumor activity.

Canonical smiles

CCOC(=O)OC1=C(C=C(C=C1SC)C=O)OC

InChi

InChI=1S/C12H14O5S/c1-4-16-12(14)17-11-9(15-2)5-8(7-13)6-10(11)18-3/h5-7H,4H2,1-3H3

InChiKey

FWZSQEQKXCQFCN-UHFFFAOYSA-N

IUPAC Name

ethyl (4-formyl-2-methoxy-6-methylsulfanylphenyl) carbonate

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 1957 Vinorelbine Tartrate. 1957-25 is the same size as the 25 mg size of ab142167.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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