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AB273620

Vistusertib (AZD2014)

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MW 462.5 Da, Purity >98%. Novel potent and selective mammalian rapamycin (mTOR) inhibitor (IC50 = 2.8 nM). Highly selective against multiple PI3K isoforms. Also targets P-Akt (IC50 = 80 nM) and pS6 (IC50 = 200 nM). An oral inhibitor with potential anti-neoplastic activity.
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Chemical Structure - Vistusertib (AZD2014) (AB273620)
  • Chemical Structure

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Chemical Structure - Vistusertib (AZD2014) (AB273620)

Chemical structure of Vistusertib (AZD2014), 1009298-59-2

Key facts

CAS number

1009298-59-2

Purity

>98%

Form

Solid

form

Molecular weight

462.5 Da

Molecular formula

C<sub>2</sub><sub>5</sub>H<sub>3</sub><sub>0</sub>N<sub>6</sub>O<sub>3</sub>

PubChem

25262792

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

Vistusertib

Biological description

Novel potent and selective mammalian rapamycin (mTOR) inhibitor (IC50 = 2.8 nM). Highly selective against multiple PI3K isoforms. Also targets P-Akt (IC50 = 80 nM) and pS6 (IC50 = 200 nM). An oral inhibitor with potential anti-neoplastic activity.

Canonical smiles

CC1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=CC=C4)C(=O)NC)N5CCOCC5C

Isomeric smiles

C[C@H]1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=CC=C4)C(=O)NC)N5CCOC[C@@H]5C

InChi

InChI=1S/C25H30N6O3/c1-16-14-33-11-9-30(16)23-20-7-8-21(18-5-4-6-19(13-18)24(32)26-3)27-22(20)28-25(29-23)31-10-12-34-15-17(31)2/h4-8,13,16-17H,9-12,14-15H2,1-3H3,(H,26,32)/t16-,17-/m0/s1

InChiKey

JUSFANSTBFGBAF-IRXDYDNUSA-N

IUPAC Name

3-[2,4-bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl]-N-methylbenzamide

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Product details

For obtaining a higher solubility, please warm the tube at 37°C and shake in the ultrasonic bath for a while.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
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Product protocols

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