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AB141439

VO-OHpic trihydrate, PTEN inhibitor

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(1 Publication)

MW 417.22 Da, Purity >98%. Potent, selective and reversible PTEN inhibitor (IC50 = 46 nM). Increases PIP3 levels, phosphorylation of Akt and glucose uptake. Active in vivo.
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Chemical Structure - VO-OHpic trihydrate, PTEN inhibitor (AB141439)
  • Chemical Structure

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Chemical Structure - VO-OHpic trihydrate, PTEN inhibitor (AB141439)

2D chemical structure image of ab141439, VO-OHpic trihydrate, PTEN inhibitor

Key facts

Purity

>98%

Form

Solid

form

Molecular weight

417.22 Da

Molecular formula

C<sub>1</sub><sub>2</sub>H<sub>1</sub><sub>8</sub>N<sub>2</sub>O<sub>1</sub><sub>1</sub>V+

PubChem

66577002

Nature

Synthetic

Solubility

Soluble in DMSO to 25 mM

Biochemical name

Hydron;hydroxy(oxo)vanadium;3-hydroxypyridine-2-carboxylic acid;trihydrate

Biological description

Potent, selective and reversible PTEN inhibitor (IC50 = 46 nM). Increases PIP3 levels, phosphorylation of Akt and glucose uptake. Active in vivo.

Canonical smiles

[H+].C1=CC(=C(N=C1)C(=O)O)O.C1=CC(=C(N=C1)C(=O)O)O.O.O.O.O[V]=O

InChi

InChI=1S/2C6H5NO3.4H2O.O.V/c2*8-4-2-1-3-7-5(4)6(9)10;;;;;;/h2*1-3,8H,(H,9,10);4*1H2;;/q;;;;;;;+1

InChiKey

OWDNSCJMZFXFMO-UHFFFAOYSA-N

IUPAC Name

hydron;hydroxy(oxo)vanadium;3-hydroxypyridine-2-carboxylic acid;trihydrate

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 1801 VO-OHpic, Trihydrate. 1801-25 is the same size as the 25 mg size of ab141439.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncotarget 9:24778-24786 PubMed29872505

2018

Expression of P-REX2a is associated with poor prognosis in endometrial malignancies.

Applications

Unspecified application

Species

Unspecified reactive species

Sho Takeshita,Yoriko Yamashita,Kosuke Shiomi,Nako Suzuki,Jun Yoshida,Aya Naiki-Ito,Shugo Suzuki,Shinya Akatsuka,Shinya Toyokuni,Takashi Takahashi,Shoko Mase,Atsushi Arakawa,Mayumi Sugiura-Ogasawara,Satoru Takahashi
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