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MW 461.5 Da, Purity >=98%. Potassium-competitive acid blocker (P-CAB) that inhibits gastric H⁺/K⁺ATPase (IC₅₀ = 17 nM) but does not inhibit porcine Na+/K+ ATPase activity when used at a concentration of 10 μM.

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Key facts

CAS number
881681-01-2
Purity
>= 98%
Form
Solid
Molecular weight
461.5 Da
Molecular formula
C21H20FN3O6S
PubChem identifier
45375887
Nature
Synthetic

Target data

Recommended products

MW 461.5 Da, Purity >=98%. Potassium-competitive acid blocker (P-CAB) that inhibits gastric H⁺/K⁺ATPase (IC₅₀ = 17 nM) but does not inhibit porcine Na+/K+ ATPase activity when used at a concentration of 10 μM.

Key facts

Purity
>= 98%
PubChem identifier
45375887
Solubility

Soluble in DMSO.

Biochemical name
Vonoprazan Fumarate
Biological description

Potassium-competitive acid blocker (P-CAB) that inhibits gastric H⁺/K⁺ATPase (IC₅₀ = 17 nM) but does not inhibit porcine Na+/K+ ATPase activity when used at a concentration of 10 μM.

Canonical SMILES
CNCC1=CN(C(=C1)C2=CC=CC=C2F)S(=O)(=O)C3=CN=CC=C3.C(=CC(=O)O)C(=O)O
Isomeric SMILES
CNCC1=CN(C(=C1)C2=CC=CC=C2F)S(=O)(=O)C3=CN=CC=C3.C(=C/C(=O)O)\C(=O)O
InChI
InChI=1S/C17H16FN3O2S.C4H4O4/c1-19-10-13-9-17(15-6-2-3-7-16(15)18)21(12-13)24(22,23)14-5-4-8-20-11-14;5-3(6)1-2-4(7)8/h2-9,11-12,19H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
InChIKey
ROGSHYHKHPCCJW-WLHGVMLRSA-N
IUPAC name
(E)-but-2-enedioic acid;1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonylpyrrol-3-yl]-N-methylmethanamine

Storage

Shipped at conditions
Blue Ice
Appropriate long-term storage conditions
-20°C
Storage information
This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes

Notes

This product is manufactured by BioVision, an Abcam company and was previously called B2292 Vonoprazan fumarate. B2292-250 is the same size as the 250 mg size of ab286991.

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