VU0155041, positive allosteric mGluR4 agonist

Key facts

CAS number

1093757-42-6

Purity

>99%

Form

Solid

form

Molecular weight

316.2 Da

Molecular formula

C₁₄H₁₅Cl₂NO₃

PubChem

2933724

Nature

Synthetic

Solubility

Soluble in 1 eq. NaOH to 100 mM

Soluble in DMSO to 100 mM

Soluble in ethanol to 50 mM

Biochemical name

2-[(3,5-dichlorophenyl)carbamoyl]cyclohexane-1-carboxylic Acid

Biological description

Positive allosteric selective modulator at mGluR4 (EC50 values are 798 and 693 nM at human and rat mGluR4 receptors, respectively). It has advantages over PHCCC (ab120043) as it is more potent. Shows limited blood-brain barrier permeability. Active in behavioural models of Parkinson's disease following icv injection. Available in water-soluble form - please see VU0155041 sodium salt (ab120248).

Canonical smiles

C1CCC(C(C1)C(=O)NC2=CC(=CC(=C2)Cl)Cl)C(=O)O

InChi

InChI=1S/C14H15Cl2NO3/c15-8-5-9(16)7-10(6-8)17-13(18)11-3-1-2-4-12(11)14(19)20/h5-7,11-12H,1-4H2,(H,17,18)(H,19,20)

InChiKey

VSMUYYFJVFSVCA-UHFFFAOYSA-N

IUPAC Name

2-[(3,5-dichlorophenyl)carbamoyl]cyclohexane-1-carboxylic acid