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MW 297.31 Da, Purity >98%. Cell-permeable Janus kinase 3 (JAK3) inhibitor (IC50 values of 9.1 μM and 78 μM for human and mouse recombinant proteins respectively). Selective versus JAK1, JAK2, SYK, BTK and LYN tyrosine kinases.

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Images

Chemical Structure - WHI-P131 hydrochloride, JAK3 inhibitor (AB142126), expandable thumbnail

Key facts

CAS number
202475-60-3
Purity
> 98%
Form
Solid
Molecular weight
297.31 Da
Molecular formula
C16H15N3O3
PubChem identifier
3794
Nature
Synthetic

Target data

Recommended products

MW 297.31 Da, Purity >98%. Cell-permeable Janus kinase 3 (JAK3) inhibitor (IC50 values of 9.1 μM and 78 μM for human and mouse recombinant proteins respectively). Selective versus JAK1, JAK2, SYK, BTK and LYN tyrosine kinases.

Key facts

Purity
> 98%
PubChem identifier
3794
Solubility

Soluble in DMSO to 100 mM.

Biochemical name
Janex-1
Biological description

Cell-permeable Janus kinase 3 (JAK3) inhibitor (IC50 values of 9.1 μM and 78 μM for human and mouse recombinant proteins respectively). Selective versus JAK1, JAK2, SYK, BTK and LYN tyrosine kinases.

Canonical SMILES
COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)O)OC
InChI
InChI=1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-3-5-11(20)6-4-10/h3-9,20H,1-2H3,(H,17,18,19)
InChIKey
HOZUXBLMYUPGPZ-UHFFFAOYSA-N
IUPAC name
4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C

Product promise

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1 product image

  • Chemical Structure - WHI-P131 hydrochloride, JAK3 inhibitor (ab142126), expandable thumbnail

    Chemical Structure - WHI-P131 hydrochloride, JAK3 inhibitor (ab142126)

    2D chemical structure image of ab142126, WHI-P131 hydrochloride, JAK3 inhibitor

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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