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AB142126

WHI-P131 hydrochloride, JAK3 inhibitor

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MW 297.31 Da, Purity >98%. Cell-permeable Janus kinase 3 (JAK3) inhibitor (IC50 values of 9.1 μM and 78 μM for human and mouse recombinant proteins respectively). Selective versus JAK1, JAK2, SYK, BTK and LYN tyrosine kinases.
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Chemical Structure - WHI-P131 hydrochloride, JAK3 inhibitor (AB142126)
  • Chemical Structure

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Chemical Structure - WHI-P131 hydrochloride, JAK3 inhibitor (AB142126)

2D chemical structure image of ab142126, WHI-P131 hydrochloride, JAK3 inhibitor

Key facts

CAS number

202475-60-3

Purity

>98%

Form

Solid

form

Molecular weight

297.31 Da

Molecular formula

C<sub>1</sub><sub>6</sub>H<sub>1</sub><sub>5</sub>N<sub>3</sub>O<sub>3</sub>

PubChem

3794

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

Janex-1

Biological description

Cell-permeable Janus kinase 3 (JAK3) inhibitor (IC50 values of 9.1 μM and 78 μM for human and mouse recombinant proteins respectively). Selective versus JAK1, JAK2, SYK, BTK and LYN tyrosine kinases.

Canonical smiles

COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)O)OC

InChi

InChI=1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-3-5-11(20)6-4-10/h3-9,20H,1-2H3,(H,17,18,19)

InChiKey

HOZUXBLMYUPGPZ-UHFFFAOYSA-N

IUPAC Name

4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
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Product protocols

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