MW 426.1 Da, Purity >99%. Selective neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. Binds the GTPase binding domain stabilising the autoinhibited conformation. Prevents activation of Arp2/3 complex in the actin cytoskeleton.
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- Journal of cellular physiology 238:1063-10792023Identification of circular dorsal ruffles as signal platforms for the AKT pathway in glomerular podocytes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRui Hua,Jinzi Wei,Mauricio Torres,Yuxin He,Yanan Li,Xiaowei Sun,Li Wang,Ken Inoki,Sei YoshidaPubMed 36924084
- Development (Cambridge, England) 149:2022N-WASP-Arp2/3 signaling controls multiple steps of dendrite maturation in Purkinje cells in vivo.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKoichi Hasegawa,Takeshi K Matsui,Junpei Kondo,Ken-Ichiro KuwakoPubMed 36469048
- Neuron 93:854-866.e42017Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTolga Soykan,Natalie Kaempf,Takeshi Sakaba,Dennis Vollweiter,Felix Goerdeler,Dmytro Puchkov,Natalia L Kononenko,Volker HauckePubMed 28231467
- Journal of cell science 127:1052-10642014Podosomes of dendritic cells facilitate antigen sampling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMaksim Baranov et. al.PubMed 24424029
Key facts
- CAS number
- 253449-04-6
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 426.1 Da
- Molecular formula
- C17H18Br2N2O
- PubChem identifier
- 2775510
- Nature
- Synthetic
Target data
Alternative names
AI413597, AW045860, DDPAC, FLJ31424, FTDP 17, G protein beta1/gamma2 subunit interacting factor 1, MAPT, MAPTL, MGC134287, MGC138549, MGC156663, MGC2124, MGC60244, MSTD, MTBT1, MTBT2, Microtubule associated protein tau isoform 4, Microtubule-associated protein tau, Mtapt, Neurofibrillary tangle protein, PHF-tau, PPND, PPP1R103, Paired helical filament-tau, Protein phosphatase 1, regulatory subunit 103, RGP 4, RGS4_HUMAN, RNPTAU, Regulator of G protein signalling 4, Regulator of G-protein signaling 4, SCZD 9, Schizophrenia disorder 9, TAU_HUMAN, Tauopathy and respiratory failure, Tauopathy and respiratory failure, included, pTau
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MW 426.1 Da, Purity >99%. Selective neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. Binds the GTPase binding domain stabilising the autoinhibited conformation. Prevents activation of Arp2/3 complex in the actin cytoskeleton.
Key facts
- CAS number
- 253449-04-6
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 426.1 Da
- Molecular formula
- C17H18Br2N2O
- PubChem identifier
- 2775510
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
- Biochemical name
- Wiskostatin
- Biological description
Selective neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. Binds the GTPase binding domain stabilising the autoinhibited conformation. Prevents activation of Arp2/3 complex in the actin cytoskeleton.
- Canonical SMILES
- CN(C)CC(CN1C2=C(C=C(C=C2)Br)C3=C1C=CC(=C3)Br)O
- InChI
- InChI=1S/C17H18Br2N2O/c1-20(2)9-13(22)10-21-16-5-3-11(18)7-14(16)15-8-12(19)4-6-17(15)21/h3-8,13,22H,9-10H2,1-2H3
- InChIKey
- XUBJEDZHBUPBKL-UHFFFAOYSA-N
- IUPAC name
- 1-(3,6-dibromocarbazol-9-yl)-3-(dimethylamino)propan-2-ol
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- The product can be stored for up to 12 months
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Tau also known as MAPT (Microtubule-Associated Protein Tau) is a protein that primarily functions in stabilizing microtubules. It plays an essential role in ensuring proper neuronal cell shape and intracellular transport. Tau has several isoforms generated through alternate splicing each with a specific mass ranging from 45 to 68 kDa. This protein is abundantly found in neurons within the central nervous system although its presence has also been detected in other cell types but at much lower levels.
- Biological function summary
Tau acts to stabilize microtubules which are structural components critical for maintaining neuronal morphology and function. It may also interact with actin filaments and other cytoskeletal proteins. Tau’s stabilization of microtubules is important for axonal transport a process that delivers essential nutrients and signaling molecules across cells. tau is often associated with complexes involving cytoskeletal elements and various microtubule-associated proteins.
- Pathways
The role of Tau plays in cellular signaling and transport makes it an important component of pathways like the MAPK/ERK pathway and PI3K/AKT signaling. These pathways are involved in cell differentiation survival and proliferation. Other notable proteins that share these pathways include amyloid precursor protein (APP) and glycogen synthase kinase 3 beta (GSK-3β). Tau's hyperphosphorylation can disrupt these pathways adversely affecting neuronal health.
- Associated diseases and disorders
The aggregation and malfunction of Tau are intensely linked to Alzheimer's disease and frontotemporal dementia. Abnormal phosphorylation of Tau leads to the formation of neurofibrillary tangles a hallmark of Alzheimer's pathology. In these conditions Tau interacts with proteins such as amyloid-beta (Aβ) found in amyloid plaques. These pathologies highlight Tau’s role not just as a structural protein but as a critical factor in neurodegenerative processes.
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1 product image
Chemical Structure - Wiskostatin, N-WASP inhibitor (ab141085)
2D chemical structure image of ab141085, Wiskostatin, N-WASP inhibitor
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