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AB141440

WP1066, JAK/STAT3 inhibitor

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MW 356.2 Da, Purity >97%. JAK/STAT3 inhibitor (IC50 = 2.3 μM). More potent analog of AG 490 (ab120950). Antitumor activity in vitro and in vivo. Blood-brain barrier permeable.
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Chemical Structure - WP1066, JAK/STAT3 inhibitor (AB141440)
  • Chemical Structure

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Chemical Structure - WP1066, JAK/STAT3 inhibitor (AB141440)

2D chemical structure image of ab141440, WP1066, JAK/STAT3 inhibitor

Key facts

CAS number

857064-38-1

Purity

>97%

Form

Solid

form

Molecular weight

356.2 Da

Molecular formula

C<sub>1</sub><sub>7</sub>H<sub>1</sub><sub>4</sub>BrN<sub>3</sub>O

PubChem

11210478

Nature

Synthetic

Solubility

Soluble in DMSO to 25 mM and in ethanol to 10 mM

Biochemical name

(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide

Biological description

JAK/STAT3 inhibitor (IC50 = 2.3 μM). More potent analog of AG 490 (ab120950). Antitumor activity in vitro and in vivo. Blood-brain barrier permeable.

Canonical smiles

CC(C1=CC=CC=C1)NC(=O)C(=CC2=NC(=CC=C2)Br)C#N

Isomeric smiles

C[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N

InChi

InChI=1S/C17H14BrN3O/c1-12(13-6-3-2-4-7-13)20-17(22)14(11-19)10-15-8-5-9-16(18)21-15/h2-10,12H,1H3,(H,20,22)/b14-10+/t12-/m0/s1

InChiKey

VFUAJMPDXIRPKO-LQELWAHVSA-N

IUPAC Name

(E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 1809 WP1066. 1809-25 is the same size as the 25 mg size of ab141440.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Product promise

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