MW 356.2 Da, Purity >97%. JAK/STAT3 inhibitor (IC50 = 2.3 μM). More potent analog of AG 490 (ab120950). Antitumor activity in vitro and in vivo. Blood-brain barrier permeable.
Also available as a solid (ab141440).
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Publications
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- British journal of cancer 102:1592-92010STAT3 inhibitor WP1066 as a novel therapeutic agent for renal cell carcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesA Horiguchi et. al.PubMed 20461084
- Clinical cancer research : an official journal of the American Association for Cancer Research 14:788-962008WP1066, a novel JAK2 inhibitor, suppresses proliferation and induces apoptosis in erythroid human cells carrying the JAK2 V617F mutation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSrdan Verstovsek,Taghi Manshouri,Alfonso Quintás-Cardama,David Harris,Jorge Cortes,Francis J Giles,Hagop Kantarjian,Waldemar Priebe,Zeev EstrovPubMed 18245540
- Oncogene 26:2435-442006A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo.Applications:Unspecified applicationReactive species:Unspecified reactive speciesA Iwamaru,S Szymanski,E Iwado,H Aoki,T Yokoyama,I Fokt,K Hess,C Conrad,T Madden,R Sawaya,S Kondo,W Priebe,Y KondoPubMed 17043651
Key facts
- CAS number
857064-38-1
- Purity
> 97%
- Form
Solid
- Molecular weight
356.2 Da
- Molecular formula
C17H14BrN3O
- PubChem identifier
11210478
- Nature
Synthetic
Recommended products
MW 356.2 Da, Purity >97%. JAK/STAT3 inhibitor (IC50 = 2.3 μM). More potent analog of AG 490 (ab120950). Antitumor activity in vitro and in vivo. Blood-brain barrier permeable.
Also available as a solid (ab141440).
Key facts
- CAS number
857064-38-1
- Purity
> 97%
- Form
Solid
- Molecular weight
356.2 Da
- Molecular formula
C17H14BrN3O
- PubChem identifier
11210478
- Nature
Synthetic
- Biochemical name
(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide
- Biological description
JAK/STAT3 inhibitor (IC50 = 2.3 μM). More potent analog of AG 490 (ab120950). Antitumor activity in vitro and in vivo. Blood-brain barrier permeable.
Also available as a solid (ab141440).- Canonical SMILES
CC(C1=CC=CC=C1)NC(=O)C(=CC2=NC(=CC=C2)Br)C#N
- Isomeric SMILES
C[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N
- InChI
InChI=1S/C17H14BrN3O/c1-12(13-6-3-2-4-7-13)20-17(22)14(11-19)10-15-8-5-9-16(18)21-15/h2-10,12H,1H3,(H,20,22)/b14-10+/t12-/m0/s1
- InChIKey
VFUAJMPDXIRPKO-LQELWAHVSA-N
- IUPAC name
(E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
Notes
This product is manufactured by BioVision, an Abcam company and was previously called 1809 WP1066. 1809-25 is the same size as the 25 mg size of ab141440.
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1 product image
Chemical Structure - WP1066, JAK/STAT3 inhibitor (ab141440)
2D chemical structure image of ab141440, WP1066, JAK/STAT3 inhibitor
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