WY 14643, PPARalpha agonist

Key facts

CAS number

50892-23-4

Purity

>99%

Form

Solid

form

Molecular weight

323.8 g/mol

Molecular formula

C₁₄H₁₄ClN₃O₂S

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biological description

Selective PPARα agonist (EC₅₀ values are 0.63, 32 and >100 μM at PPARα, PPARγ and PPARδ receptors respectively). Able to reduce inflammatory responses in vivo and in vitro.

Canonical smiles

CC2CCCC(NC1CC(CL)NC(SCC(=O)O)N1)C2C

InChi

InChI=1S/C14H14ClN3O2S/c1-8-4-3-5-10(9(8)2)16-12-6-11(15)17-14(18-12)21-7-13(19)20/h3-6H,7H2,1-2H3,(H,19,20)(H,16,17,18)

InChiKey

SZRPDCCEHVWOJX-UHFFFAOYSA-N

IUPAC Name

2-[[4-Chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]acetic acid