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AB144820

WZ 4003, NUAK kinase inhibitor

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(1 Publication)

MW 497 Da, Purity >98%. Potent, selective NUAK kinase inhibitor (IC50 values are 20 and 100 nM for NUAK1 and NUAK2, respectively). Impairs invasive potential of U2OS cells. Shows antiproliferative effects.
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Chemical Structure - WZ 4003, NUAK kinase inhibitor (AB144820)
  • Chemical Structure

Lab

Chemical Structure - WZ 4003, NUAK kinase inhibitor (AB144820)

2D chemical structure image of ab144820, WZ 4003, NUAK kinase inhibitor

Key facts

CAS number

1214265-58-3

Purity

>98%

Form

Solid

form

Molecular weight

497 Da

Molecular formula

C<sub>2</sub><sub>5</sub>H<sub>2</sub><sub>9</sub>ClN<sub>6</sub>O<sub>3</sub>

PubChem

72200024

Nature

Synthetic

Solubility

Soluble in DMSO to 25 mM

Biochemical name

N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)propionamide

Biological description

Potent, selective NUAK kinase inhibitor (IC50 values are 20 and 100 nM for NUAK1 and NUAK2, respectively). Impairs invasive potential of U2OS cells. Shows antiproliferative effects.

Canonical smiles

CCC(=O)NC1=CC(=CC=C1)OC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCN(CC4)C)OC

InChi

InChI=1S/C25H29ClN6O3/c1-4-23(33)28-17-6-5-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)34-3)32-12-10-31(2)11-13-32/h5-9,14-16H,4,10-13H2,1-3H3,(H,28,33)(H,27,29,30)

InChiKey

SDGJBAUIGHSMRI-UHFFFAOYSA-N

IUPAC Name

N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]propanamide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Neuron 92:407-418 PubMed27720485

2016

Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model.

Applications

Unspecified application

Species

Unspecified reactive species

Cristian A Lasagna-Reeves,Maria de Haro,Shuang Hao,Jeehye Park,Maxime W C Rousseaux,Ismael Al-Ramahi,Paymaan Jafar-Nejad,Luis Vilanova-Velez,Lauren See,Antonia De Maio,Larissa Nitschke,Zhenyu Wu,Juan C Troncoso,Thomas F Westbrook,Jianrong Tang,Juan Botas,Huda Y Zoghbi
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