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MW 497 Da, Purity >98%. Potent, selective NUAK kinase inhibitor (IC50 values are 20 and 100 nM for NUAK1 and NUAK2, respectively). Impairs invasive potential of U2OS cells. Shows antiproliferative effects.

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Images

Chemical Structure - WZ 4003, NUAK kinase inhibitor (AB144820), expandable thumbnail

Publications

Key facts

CAS number
1214265-58-3
Purity
> 98%
Form
Solid
Molecular weight
497 Da
Molecular formula
C25H29ClN6O3
PubChem identifier
72200024
Nature
Synthetic

Target data

Recommended products

MW 497 Da, Purity >98%. Potent, selective NUAK kinase inhibitor (IC50 values are 20 and 100 nM for NUAK1 and NUAK2, respectively). Impairs invasive potential of U2OS cells. Shows antiproliferative effects.

Key facts

Purity
> 98%
PubChem identifier
72200024
Solubility

Soluble in DMSO to 25 mM.

Biochemical name
N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)propionamide
Biological description

Potent, selective NUAK kinase inhibitor (IC50 values are 20 and 100 nM for NUAK1 and NUAK2, respectively). Impairs invasive potential of U2OS cells. Shows antiproliferative effects.

Canonical SMILES
CCC(=O)NC1=CC(=CC=C1)OC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCN(CC4)C)OC
InChI
InChI=1S/C25H29ClN6O3/c1-4-23(33)28-17-6-5-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)34-3)32-12-10-31(2)11-13-32/h5-9,14-16H,4,10-13H2,1-3H3,(H,28,33)(H,27,29,30)
InChIKey
SDGJBAUIGHSMRI-UHFFFAOYSA-N
IUPAC name
N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]propanamide

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

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1 product image

  • Chemical Structure - WZ 4003, NUAK kinase inhibitor (ab144820), expandable thumbnail

    Chemical Structure - WZ 4003, NUAK kinase inhibitor (ab144820)

    2D chemical structure image of ab144820, WZ 4003, NUAK kinase inhibitor

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Product protocols

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