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MW 312.31 g/mol, Purity >98%. Potent tankyrase (TNKS) inhibitor. Inhibitor of Wnt/β-catenin signaling. (IC50 values are 11 and 4 nM for TNKS1 and 2, respectively). Inhibits TNKS PARP activity. Selectivity over other PARP enzymes and CRE, NK-κB and TGF-β.
Alternative names=ADP-ribosyltransferase diphtheria toxin-like 5, OTTHUMP00000115550, OTTHUMP00000224675, PARP 5a, PARPL, Poly [ADP-ribose] polymerase 5A, TANK 1, TIN 1, TINF 1, TNKS, TNKS1_HUMAN, TRF1-interacting ankyrin-related ADP-ribose polymerase, Tankyrase I, Tankyrase TRF1 interacting ankyrin related ADP ribose polymerase, Tankyrase-1, pART5
- CAS number
284028-89-3
- Purity
> 98%
- Form
Solid
- Molecular weight
312.31 g/mol
- Molecular formula
C14H11F3N2OS
- Nature
Synthetic
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MW 312.31 g/mol, Purity >98%. Potent tankyrase (TNKS) inhibitor. Inhibitor of Wnt/β-catenin signaling. (IC50 values are 11 and 4 nM for TNKS1 and 2, respectively). Inhibits TNKS PARP activity. Selectivity over other PARP enzymes and CRE, NK-κB and TGF-β.
Alternative names=ADP-ribosyltransferase diphtheria toxin-like 5, OTTHUMP00000115550, OTTHUMP00000224675, PARP 5a, PARPL, Poly [ADP-ribose] polymerase 5A, TANK 1, TIN 1, TINF 1, TNKS, TNKS1_HUMAN, TRF1-interacting ankyrin-related ADP-ribose polymerase, Tankyrase I, Tankyrase TRF1 interacting ankyrin related ADP ribose polymerase, Tankyrase-1, pART5
Key facts
- CAS number
284028-89-3
- Purity
> 98%
- Form
Solid
- Molecular weight
312.31 g/mol
- Molecular formula
C14H11F3N2OS
- Nature
Synthetic
- Biological description
Potent tankyrase (TNKS) inhibitor. Inhibitor of Wnt/β-catenin signaling. (IC50 values are 11 and 4 nM for TNKS1 and 2, respectively). Inhibits TNKS PARP activity. Selectivity over other PARP enzymes and CRE, NK-κB and TGF-β.
- Canonical SMILES
OC1=NC(C2=CC=C(C(F)(F)F)C=C2)=NC3=C1CSCC3
- IUPAC name
3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
Ambient
- Storage information
The product can be stored for up to 12 months
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