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AB120914

Xestospongin C, IP3 receptor antagonist

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(16 Publications)

MW 446.72 g/mol, Purity >90%. Potent, selective, reversible IP3 receptor antagonist (IC50 = 350 nM). Inhibits IP3-mediated Ca2+ release from ER and SR. 30-Fold selectivity over ryanodine receptor. Inhibits voltage-dependent Ca2+ and K+ channels at higher concentrations. Cell-permeable.
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Chemical Structure - Xestospongin C, IP3 receptor antagonist (AB120914)
  • Chemical Structure

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Chemical Structure - Xestospongin C, IP3 receptor antagonist (AB120914)

2D chemical structure image of ab120914, Xestospongin C, IP3 receptor antagonist

Key facts

CAS number

88903-69-9

Purity

>90%

Form

Solid

form

Molecular weight

446.72 g/mol

Nature

Synthetic

Solubility

Soluble in DMSO to 2 mM

Soluble in ethanol to 2 mM

Biological description

Potent, selective, reversible IP3 receptor antagonist (IC50 = 350 nM). Inhibits IP3-mediated Ca2+ release from ER and SR. 30-Fold selectivity over ryanodine receptor. Inhibits voltage-dependent Ca2+ and K+ channels at higher concentrations. Cell-permeable.

Isomeric smiles

C1CCC[C@H]2CCCN3CCC(CCCCCCC4CCCN5CCC(CC1)O[C@H]45)O[C@H]23

IUPAC Name

(1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine

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Complementary Products

Biochemicals

AB120083

Ryanodine, Ca2+ release modulator

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Biochemicals

AB120503

BAPTA-AM, Ca2+ chelator

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Biochemicals

AB120124

2-APB, Ca2+ release modulator

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Biochemicals

AB120286

Thapsigargin, Ca2+-ATPase inhibitor

Functional Studies - Thapsigargin, Ca2+-ATPase inhibitor (AB120286)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this product is reported to be light sensitive|Store in the dark|Store under desiccating conditions
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Product protocols

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Publications (16)

Recent publications for all applications. Explore the full list and refine your search

Journal of translational medicine 23:366 PubMed40128893

2025

Mfn2 regulates calcium homeostasis and suppresses PASMCs proliferation via interaction with IP3R3 to mitigate pulmonary arterial hypertension.

Applications

Unspecified application

Species

Unspecified reactive species

Rui Wang,Jie Wang,Jing Yu,Zhiqiang Li,Minfang Zhang,Yuhu Chen,Fen Liu,Dongmei Jiang,Jingfei Guo,Xiaomei Li,Yun Wu

Molecular biology of the cell 35:ar92 PubMed38758660

2024

A PACAP-activated network for secretion requires coordination of Ca influx and Ca mobilization.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaohuan Chen,Nicole A Bell,Breanna L Coffman,Agustin A Rabino,Rafael Garcia-Mata,Paul J Kammermeier,David I Yule,Daniel Axelrod,Alan V Smrcka,David R Giovannucci,Arun Anantharam

iScience 27:109665 PubMed38646167

2024

The endoplasmic reticulum plays a key role in α-cell intracellular Ca dynamics and glucose-regulated glucagon secretion in mouse islets.

Applications

Unspecified application

Species

Unspecified reactive species

Samuel Acreman,Jinfang Ma,Geoffrey Denwood,Rui Gao,Andrei Tarasov,Patrik Rorsman,Quan Zhang

Molecular biology of the cell 35:ar5 PubMed37910189

2023

Signaling pathways regulating the extracellular digestion of lipoprotein aggregates by macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Noah Steinfeld,Cheng-I J Ma,Frederick R Maxfield

eLife 12: PubMed37404129

2023

Cholinergic modulation shifts the response of CA1 pyramidal cells to depolarizing ramps via TRPM4 channels with potential implications for place field firing.

Applications

Unspecified application

Species

Unspecified reactive species

Crescent L Combe,Carol M Upchurch,Carmen C Canavier,Sonia Gasparini

Nature communications 13:1257 PubMed35273168

2022

iRhom pseudoproteases regulate ER stress-induced cell death through IP receptors and BCL-2.

Applications

Unspecified application

Species

Unspecified reactive species

Iqbal Dulloo,Peace Atakpa-Adaji,Yi-Chun Yeh,Clémence Levet,Sonia Muliyil,Fangfang Lu,Colin W Taylor,Matthew Freeman

The Journal of biological chemistry 298:101740 PubMed35182526

2022

Inositol triphosphate-triggered calcium release from the endoplasmic reticulum induces lysosome biogenesis via TFEB/TFE3.

Applications

Unspecified application

Species

Unspecified reactive species

Mouhannad Malek,Anna M Wawrzyniak,Michael Ebner,Dmytro Puchkov,Volker Haucke

Biomaterials 259:120283 PubMed32827796

2020

Bile canaliculi contract autonomously by releasing calcium into hepatocytes via mechanosensitive calcium channel.

Applications

Unspecified application

Species

Unspecified reactive species

Kapish Gupta,Inn Chuan Ng,Gowri Manohari Balachander,Binh P Nguyen,Lisa Tucker-Kellogg,Boon Chuan Low,Hanry Yu

Biochemical pharmacology 174:113832 PubMed32006470

2020

Melatonin fine-tunes intracellular calcium signals and eliminates myocardial damage through the IP3R/MCU pathways in cardiorenal syndrome type 3.

Applications

Unspecified application

Species

Unspecified reactive species

Jin Wang,Sam Toan,Ruibing Li,Hao Zhou

Neuroscience 416:268-280 PubMed31425734

2019

ROS-Mediated Mitochondrial Dysfunction and ER Stress Contribute to Compression-Induced Neuronal Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Tao Chen,Jie Zhu,Yu-Hai Wang,Chun-Hua Hang
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