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MW 320.3 Da, Purity >99%. Selective Rho kinase inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.

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Images

Chemical Structure - Y-27632 dihydrochloride (mM/ml), Rho kinase inhibitor (AB144494), expandable thumbnail
  • Functional Studies - Y-27632 dihydrochloride (mM/ml), Rho kinase inhibitor (AB144494), expandable thumbnail

Publications

Key facts

CAS number

129830-38-2

Purity

> 99%

Form

Solid

Molecular weight

320.3 Da

Molecular formula

C14H23Cl2N3O

PubChem identifier

9901617

Nature

Synthetic

Target data

Alternative names

CP2D6_HUMAN, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, Cardiolipin activated protein kinase Pak2, Cholesterol 25-hydroxylase, Cytochrome P450 2D6, Cytochrome P450 family 2 subfamily D member 6, Cytochrome P450 family 2 subfamily D polypeptide 6, Cytochrome P450-DB1, Debrisoquine 4-hydroxylase, KIAA0619, KPCE_HUMAN, MGC125656, MGC125657, MGC131603, MGC150606, MGC43611, MGC71074, Microsomal monooxygenase, P450 DB1, P450C2D, PKCE, PKN gamma, PKN2_HUMAN, PRK2, PRKCE, PRKCL2, PRO0435, PRO2042, Pkcea, Protein kinase C epsilon, Protein kinase C epsilon type, Protein kinase C-like 2, Protein kinase N2, Protein-kinase C-related kinase 2, ROCK-I, ROCK1_HUMAN, ROCK2_HUMAN, ROK alpha, Renal carcinoma antigen NY-REN-35, Rho associated coiled coil containing protein kinase 1, Rho associated coiled coil containing protein kinase 2, Rho associated, coiled coil containing protein kinase II, Rho kinase, Rho kinase 2, Rho-alpha kinase, Rho-associated, Rho-associated protein kinase 1, Rho-associated protein kinase 2, Rock II, Rock2m, Rok, Serine/threonine-protein kinase N2, Xenobiotic monooxygenase, coiled-coil-containing protein kinase 1, coiled-coil-containing protein kinase 2, coiled-coil-containing protein kinase I, flavoprotein-linked monooxygenase, nPKC-epsilon, p160 ROCK, p160 ROCK-1, p160 Rhoassociated coiled coil-forming protein kinase, p164 ROCK-2

Recommended products

MW 320.3 Da, Purity >99%. Selective Rho kinase inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.

Alternative names

CP2D6_HUMAN, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, Cardiolipin activated protein kinase Pak2, Cholesterol 25-hydroxylase, Cytochrome P450 2D6, Cytochrome P450 family 2 subfamily D member 6, Cytochrome P450 family 2 subfamily D polypeptide 6, Cytochrome P450-DB1, Debrisoquine 4-hydroxylase, KIAA0619, KPCE_HUMAN, MGC125656, MGC125657, MGC131603, MGC150606, MGC43611, MGC71074, Microsomal monooxygenase, P450 DB1, P450C2D, PKCE, PKN gamma, PKN2_HUMAN, PRK2, PRKCE, PRKCL2, PRO0435, PRO2042, Pkcea, Protein kinase C epsilon, Protein kinase C epsilon type, Protein kinase C-like 2, Protein kinase N2, Protein-kinase C-related kinase 2, ROCK-I, ROCK1_HUMAN, ROCK2_HUMAN, ROK alpha, Renal carcinoma antigen NY-REN-35, Rho associated coiled coil containing protein kinase 1, Rho associated coiled coil containing protein kinase 2, Rho associated, coiled coil containing protein kinase II, Rho kinase, Rho kinase 2, Rho-alpha kinase, Rho-associated, Rho-associated protein kinase 1, Rho-associated protein kinase 2, Rock II, Rock2m, Rok, Serine/threonine-protein kinase N2, Xenobiotic monooxygenase, coiled-coil-containing protein kinase 1, coiled-coil-containing protein kinase 2, coiled-coil-containing protein kinase I, flavoprotein-linked monooxygenase, nPKC-epsilon, p160 ROCK, p160 ROCK-1, p160 Rhoassociated coiled coil-forming protein kinase, p164 ROCK-2

Key facts

Purity

> 99%

PubChem identifier

9901617

Biochemical name

(1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride

Biological description

Selective Rho kinase inhibitor.

Canonical SMILES

CC(C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl

Isomeric SMILES

C[C@H](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl

InChI

InChI=1S/C14H21N3O.2ClH/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13;;/h6-12H,2-5,15H2,1H3,(H,16,17,18);2*1H/t10-,11?,12?;;/m1../s1

InChIKey

IDDDVXIUIXWAGJ-DDSAHXNVSA-N

IUPAC name

4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide;dihydrochloride

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate long-term storage conditions

+4°C

Storage information

Store under desiccating conditions, The product can be stored for up to 12 months

Product promise

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In the unlikely event of one of our products not working as expected, you are covered by our product promise.

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Terms & Conditions.

2 product images

  • Chemical Structure - Y-27632 dihydrochloride (mM/ml), Rho kinase inhibitor (ab144494), expandable thumbnail

    Chemical Structure - Y-27632 dihydrochloride (mM/ml), Rho kinase inhibitor (ab144494)

    2D chemical structure image of ab144494, Y-27632 dihydrochloride (mM/ml), Rho kinase inhibitor

  • Functional Studies - Y-27632 dihydrochloride (mM/ml), Rho kinase inhibitor (ab144494), expandable thumbnail
    Takazawa et al PLoS One. 2012;7(7):e40154. doi: 10.1371/journal.pone.0040154. Epub 2012 Jul 3. Fig 2. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

    Functional Studies - Y-27632 dihydrochloride (mM/ml), Rho kinase inhibitor (ab144494)

    Representative morphology and membrane potential responses to current step injection in hESMNs at 3 different times in vitro.

    Imaging of cells fixed after patch-clamp recordings indicate that recorded cells express the Hb9::GFP reporter transgene (A-C,E,G,and I). Voltage responses and imaging in the same rows are taken from same neurons. The neurons for A-C are same as that shown in F and G. D,F,H show examples of voltage responses to current steps recorded from 3 neurons current-clamped at −58 mV, −60 mV, and −55 mV, respectively. Bottom traces in D,F, and H show injected currents. Scale bars in images are 50 μm.

    Only part of full image panel shown.

    Cells were pre-treated with ab144494.

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Product protocols

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