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MW 320.3 Da, Purity >=99%. Selective Rho kinase inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.
Alternative names=CP2D6_HUMAN, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, Cardiolipin activated protein kinase Pak2, Cholesterol 25-hydroxylase, Cytochrome P450 2D6, Cytochrome P450 family 2 subfamily D member 6, Cytochrome P450 family 2 subfamily D polypeptide 6, Cytochrome P450-DB1, Debrisoquine 4-hydroxylase, KIAA0619, KPCE_HUMAN, MGC125656, MGC125657, MGC131603, MGC150606, MGC43611, MGC71074, Microsomal monooxygenase, P450 DB1, P450C2D, PKCE, PKN gamma, PKN2_HUMAN, PRK2, PRKCE, PRKCL2, PRO0435, PRO2042, Pkcea, Protein kinase C epsilon, Protein kinase C epsilon type, Protein kinase C-like 2, Protein kinase N2, Protein-kinase C-related kinase 2, ROCK-I, ROCK1_HUMAN, ROCK2_HUMAN, ROK alpha, Renal carcinoma antigen NY-REN-35, Rho associated coiled coil containing protein kinase 1, Rho associated coiled coil containing protein kinase 2, Rho associated, coiled coil containing protein kinase II, Rho kinase, Rho kinase 2, Rho-alpha kinase, Rho-associated, Rho-associated protein kinase 1, Rho-associated protein kinase 2, Rock II, Rock2m, Rok, Serine/threonine-protein kinase N2, Xenobiotic monooxygenase, coiled-coil-containing protein kinase 1, coiled-coil-containing protein kinase 2, coiled-coil-containing protein kinase I, flavoprotein-linked monooxygenase, nPKC-epsilon, p160 ROCK, p160 ROCK-1, p160 Rhoassociated coiled coil-forming protein kinase, p164 ROCK-2
- CAS number
129830-38-2
- Purity
>= 98%
- Form
Liquid
- Molecular weight
320.3 Da
- Molecular formula
C14H23Cl2N3O
- PubChem identifier
9901617
- Nature
Synthetic
Recommended products
MW 320.3 Da, Purity >=99%. Selective Rho kinase inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.
Alternative names=CP2D6_HUMAN, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, Cardiolipin activated protein kinase Pak2, Cholesterol 25-hydroxylase, Cytochrome P450 2D6, Cytochrome P450 family 2 subfamily D member 6, Cytochrome P450 family 2 subfamily D polypeptide 6, Cytochrome P450-DB1, Debrisoquine 4-hydroxylase, KIAA0619, KPCE_HUMAN, MGC125656, MGC125657, MGC131603, MGC150606, MGC43611, MGC71074, Microsomal monooxygenase, P450 DB1, P450C2D, PKCE, PKN gamma, PKN2_HUMAN, PRK2, PRKCE, PRKCL2, PRO0435, PRO2042, Pkcea, Protein kinase C epsilon, Protein kinase C epsilon type, Protein kinase C-like 2, Protein kinase N2, Protein-kinase C-related kinase 2, ROCK-I, ROCK1_HUMAN, ROCK2_HUMAN, ROK alpha, Renal carcinoma antigen NY-REN-35, Rho associated coiled coil containing protein kinase 1, Rho associated coiled coil containing protein kinase 2, Rho associated, coiled coil containing protein kinase II, Rho kinase, Rho kinase 2, Rho-alpha kinase, Rho-associated, Rho-associated protein kinase 1, Rho-associated protein kinase 2, Rock II, Rock2m, Rok, Serine/threonine-protein kinase N2, Xenobiotic monooxygenase, coiled-coil-containing protein kinase 1, coiled-coil-containing protein kinase 2, coiled-coil-containing protein kinase I, flavoprotein-linked monooxygenase, nPKC-epsilon, p160 ROCK, p160 ROCK-1, p160 Rhoassociated coiled coil-forming protein kinase, p164 ROCK-2
Key facts
- CAS number
129830-38-2
- Purity
>= 98%
- Form
Liquid
- Molecular weight
320.3 Da
- Molecular formula
C14H23Cl2N3O
- PubChem identifier
9901617
- Nature
Synthetic
- Biochemical name
(1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride
- Biological description
Selective Rho kinase inhibitor.
- Canonical SMILES
CC(C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl
- Isomeric SMILES
C[C@H](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl
- InChI
InChI=1S/C14H21N3O.2ClH/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13;;/h6-12H,2-5,15H2,1H3,(H,16,17,18);2*1H/t10-,11?,12?;;/m1../s1
- InChIKey
IDDDVXIUIXWAGJ-DDSAHXNVSA-N
- IUPAC name
4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide;dihydrochloride
Storage
- Shipped at conditions
Blue Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
Notes
Y-27632, Sterile-Filtered ab291110 (previously known as EZSolution Y-27632, Sterile-Filtered,1994) is a 10 mM (3.20 mg in 1 ml) solution of the ROCK inhibitor Y-27632, Dihydrochloride in deionized water.
Y-27632 is a research tool with a wide variety of biological effects, mainly used in the field of stem cell research for maintenance and differentiation. Commonly used as 3D growth matrix component; also a component of brain organoid differentiation media.
How others have used Y-27632 in their research:
Maintenance of tissue culture of iPSCs; 10 μM Y-27632 for 24 hr; Montefiori et al (2018)
Reprogramming of breast cancer cells to induced progenitor-like cells (iPLs) ; 2 μM Y27632 ; Yuan et al (2018)
Differentiation - Y-27632 enables human embryonic stem cells to survive and differentiate into cortical and basal telencephalic progenitors; Watanabe et al (2007)
*Also available in simple stock solutions (ab144494) - add 1 ml of water to get an exact, ready-to-use concentration.
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