YM-01 (YM-1), allosteric Hsp70 modulator

Key facts

CAS number

409086-68-6

Purity

>98% HPLC

Form

Solid

form

Molecular weight

417.97 g/mol

Molecular formula

C₂₀H₂₀ClN₃OS₂

Nature

Synthetic

Solubility

Soluble in water (2mg/mL)

Biological description

Allosteric Hsp70 modulator. Potent anti-tau agent. MKT-077 analog. Promotes triage functions of Hsp70. Rapidly and potently reduces tau levels ex vivo. Shows antitumor effects in vivo.

Isomeric smiles

[CL-].C[N+]4CCCCC4\C=C3/S/C(=C2/SC1CCCCC1N2C)C(=O)N3CC

InChi

InChI=1S/C20H20N3OS2.ClH/c1-4-23-17(13-14-9-7-8-12-21(14)2)26-18(19(23)24)20-22(3)15-10-5-6-11-16(15)25-20;/h5-13H,4H2,1-3H3;1H/q+1;/p-1/b20-18+;

InChiKey

KEQDCNWQIQWINZ-KPJFUTMLSA-M

IUPAC Name

2-((Z)-((E)-3-Ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)-1-methylpyridin-1-ium chloride