JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB222376

YM-155, survivin inhibitor

Be the first to review this product! Submit a review

|

(0 Publication)

MW 443.3 Da, Purity >98%. Novel small molecule potent survivin suppressant. Inhibits survivin promoter activity (IC50 = 0.54 nM) and down-regulates survivin in vitro and in vivo. Induces apoptosis in human tumor cell lines in vitro at 10 nM, with little effect on other IAP or Bcl-2 family members.

Key facts

CAS number

781661-94-7

Purity

>98%

Form

Solid

form

Molecular weight

443.3 Da

Molecular formula

C<sub>2</sub><sub>0</sub>H<sub>1</sub><sub>9</sub>BrN<sub>4</sub>O<sub>3</sub>

PubChem

11178236

Nature

Synthetic

Solubility

Soluble in DMSO to 55 mM

Biochemical name

Sepantronium bromide

Biological description

Novel small molecule potent survivin suppressant. Inhibits survivin promoter activity (IC50 = 0.54 nM) and down-regulates survivin in vitro and in vivo. Induces apoptosis in human tumor cell lines in vitro at 10 nM, with little effect on other IAP or Bcl-2 family members.

Canonical smiles

CC1=[N+](C2=C(N1CCOC)C(=O)C3=CC=CC=C3C2=O)CC4=NC=CN=C4.[Br-]

InChi

InChI=1S/C20H19N4O3.BrH/c1-13-23(9-10-27-2)17-18(24(13)12-14-11-21-7-8-22-14)20(26)16-6-4-3-5-15(16)19(17)25;/h3-8,11H,9-10,12H2,1-2H3;1H/q+1;/p-1

InChiKey

QBIYUDDJPRGKNJ-UHFFFAOYSA-M

IUPAC Name

1-(2-methoxyethyl)-2-methyl-3-(pyrazin-2-ylmethyl)benzo[f]benzimidazol-3-ium-4,9-dione;bromide

style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB32064

Anti-Cleaved PARP1 antibody [E51]

RabMAb|Recombinant|KO Validated|Lab Essentials|20ul selling size

Western blot - Anti-Cleaved PARP1 antibody [E51] (AB32064)

  • 4
  • 18
Proteins & Peptides

AB7403

Streptavidin (HRP)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Streptavidin (HRP) (AB7403)

  • 5
  • 7
Biochemicals

AB120488

Z-D(OMe)E(OMe)VD(OMe)-FMK, Cell permeable caspase-3 inhibitor

Chemical Structure - Z-D(OMe)E(OMe)VD(OMe)-FMK, Cell permeable caspase-3 inhibitor (AB120488)

  • 0
  • 0
Proteins & Peptides

AB128447

Recombinant Human UBE2M/UBC12 protein

SDS-PAGE - Recombinant Human UBE2M/UBC12 protein (AB128447)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com