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AB120015

YM298198 hydrochloride, mGlu1 antagonist

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(6 Publications)

MW 378.9 Da, Purity >99%. Potent, selective, water-soluble, non-competitive mGlu1 antagonist (IC50 = 16 nM) Selective over mGlu2,3,4,5,6, and 7 and ionotropic receptors (IC50 > 10 μM). Orally active analgesic *in vivo*. Also available in simple stock solutions (ab146667) - add 1 ml of water to get an exact, ready-to-use concentration.

View Alternative Names

GLUR, Smp_128940

1 Images
Chemical Structure - YM298198 hydrochloride, mGlu1 antagonist (AB120015)
  • Chemical Structure

Lab

Chemical Structure - YM298198 hydrochloride, mGlu1 antagonist (AB120015)

2D chemical structure image of ab120015, YM298198 hydrochloride, mGlu1 antagonist

Key facts

CAS number

748758-45-4

Purity

>99%

Form

Solid

form

Molecular weight

378.9 Da

Molecular formula

C<sub>1</sub><sub>8</sub>H<sub>2</sub><sub>3</sub>ClN<sub>4</sub>OS

PubChem

45073464

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biochemical name

YM 298198 hydrochloride

Biological description

Potent, selective, water-soluble, non-competitive mGlu1 antagonist (IC50 = 16 nM) Selective over mGlu2,3,4,5,6, and 7 and ionotropic receptors (IC50 > 10 μM). Orally active analgesic *in vivo*. Also available in simple stock solutions (ab146667) - add 1 ml of water to get an exact, ready-to-use concentration.

Canonical smiles

CC1=C(SC2=NC3=C(N12)C=C(C=C3)N)C(=O)N(C)C4CCCCC4.Cl

InChi

InChI=1S/C18H22N4OS.ClH/c1-11-16(17(23)21(2)13-6-4-3-5-7-13)24-18-20-14-9-8-12(19)10-15(14)22(11)18;/h8-10,13H,3-7,19H2,1-2H3;1H

InChiKey

WYTJVUVCSUWZTH-UHFFFAOYSA-N

IUPAC Name

7-amino-N-cyclohexyl-N,1-dimethyl-[1,3]thiazolo[3,2-a]benzimidazole-2-carboxamide;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

iScience 26:108412 PubMed38053635

2023

Amyloid-β oligomers enhance mGluR-dependent synaptic weakening via NMDAR activation and complement C5aR1 signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Ai Na Ng,Eric W Salter,John Georgiou,Zuner A Bortolotto,Graham L Collingridge

The Journal of neuroscience : the official journal of the Society for Neuroscience 35:4113-30 PubMed25762659

2015

PKA-dependent phosphorylation of ribosomal protein S6 does not correlate with translation efficiency in striatonigral and striatopallidal medium-sized spiny neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Anne Biever,Emma Puighermanal,Akinori Nishi,Alexandre David,Claire Panciatici,Sophie Longueville,Dimitris Xirodimas,Giuseppe Gangarossa,Oded Meyuhas,Denis Hervé,Jean-Antoine Girault,Emmanuel Valjent

Pflugers Archiv : European journal of physiology 466:1301-16 PubMed24121765

2013

Dual depolarization responses generated within the same lateral septal neurons by TRPC4-containing channels.

Applications

Unspecified application

Species

Mouse

Jinbin Tian,Dhananjay P Thakur,Yungang Lu,Yingmin Zhu,Marc Freichel,Veit Flockerzi,Michael X Zhu

Nature neuroscience 13:1216-24 PubMed20852624

2010

Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95.

Applications

Unspecified application

Species

Unspecified reactive species

Jihoon Jo,Gi Hoon Son,Bryony L Winters,Myung Jong Kim,Daniel J Whitcomb,Bryony A Dickinson,Youn-Bok Lee,Kensuke Futai,Mascia Amici,Morgan Sheng,Graham L Collingridge,Kwangwook Cho

The Journal of neuroscience : the official journal of the Society for Neuroscience 30:5724-9 PubMed20410124

2010

Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Longhua Zhang,Bradley E Alger

PloS one 4:e6122 PubMed19568435

2009

Novel mGluR- and CB1R-independent suppression of GABA release caused by a contaminant of the group I metabotropic glutamate receptor agonist, DHPG.

Applications

Unspecified application

Species

Unspecified reactive species

Carlos A Lafourcade,Longhua Zhang,Bradley E Alger
View all publications
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