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AB120015

YM298198 hydrochloride, mGlu1 antagonist

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(6 Publications )

MW 378.9 Da, Purity >99%. Potent, selective, water-soluble, non-competitive mGlu1 antagonist (IC50 = 16 nM) Selective over mGlu2,3,4,5,6, and 7 and ionotropic receptors (IC50 > 10 μM). Orally active analgesic *in vivo*. Also available in simple stock solutions (ab146667) - add 1 ml of water to get an exact, ready-to-use concentration.

View Alternative Names

GLUR, Smp_128940

1 Images
Chemical Structure - YM298198 hydrochloride, mGlu1 antagonist (AB120015)
  • Chemical Structure

Lab

Chemical Structure - YM298198 hydrochloride, mGlu1 antagonist (AB120015)

2D chemical structure image of ab120015, YM298198 hydrochloride, mGlu1 antagonist

Key facts

CAS number

748758-45-4

Purity

>99%

Form

Solid

form

Molecular weight

378.9 Da

Molecular formula

C<sub>1</sub><sub>8</sub>H<sub>2</sub><sub>3</sub>ClN<sub>4</sub>OS

PubChem

45073464

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biochemical name

YM 298198 hydrochloride

Biological description

Potent, selective, water-soluble, non-competitive mGlu1 antagonist (IC50 = 16 nM) Selective over mGlu2,3,4,5,6, and 7 and ionotropic receptors (IC50 > 10 μM). Orally active analgesic *in vivo*. Also available in simple stock solutions (ab146667) - add 1 ml of water to get an exact, ready-to-use concentration.

Canonical smiles

CC1=C(SC2=NC3=C(N12)C=C(C=C3)N)C(=O)N(C)C4CCCCC4.Cl

InChi

InChI=1S/C18H22N4OS.ClH/c1-11-16(17(23)21(2)13-6-4-3-5-7-13)24-18-20-14-9-8-12(19)10-15(14)22(11)18;/h8-10,13H,3-7,19H2,1-2H3;1H

InChiKey

WYTJVUVCSUWZTH-UHFFFAOYSA-N

IUPAC Name

7-amino-N-cyclohexyl-N,1-dimethyl-[1,3]thiazolo[3,2-a]benzimidazole-2-carboxamide;hydrochloride

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Complementary Products

Biochemicals

AB120007

(S)-3,5-DHPG, group I mGlu agonist

Functional Studies - (S)-3,5-DHPG, group I mGlu agonist (AB120007)

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Biochemicals

AB120003

D-AP5, NMDA glutamate site antagonist

Chemical Structure - D-AP5, NMDA glutamate site antagonist (AB120003)

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Biochemicals

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Thapsigargin, Ca2+-ATPase inhibitor

Functional Studies - Thapsigargin, Ca2+-ATPase inhibitor (AB120286)

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Biochemicals

AB120300

Cyclopiazonic acid from Penicillium grisefulvum, Ca2+-ATPase inhibitor

Chemical Structure - Cyclopiazonic acid from Penicillium grisefulvum, Ca2+-ATPase inhibitor (AB120300)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Product protocols

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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

iScience 26:108412 PubMed38053635

2023

Amyloid-β oligomers enhance mGluR-dependent synaptic weakening via NMDAR activation and complement C5aR1 signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Ai Na Ng,Eric W Salter,John Georgiou,Zuner A Bortolotto,Graham L Collingridge

The Journal of neuroscience : the official journal of the Society for Neuroscience 35:4113-30 PubMed25762659

2015

PKA-dependent phosphorylation of ribosomal protein S6 does not correlate with translation efficiency in striatonigral and striatopallidal medium-sized spiny neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Anne Biever,Emma Puighermanal,Akinori Nishi,Alexandre David,Claire Panciatici,Sophie Longueville,Dimitris Xirodimas,Giuseppe Gangarossa,Oded Meyuhas,Denis Hervé,Jean-Antoine Girault,Emmanuel Valjent

Pflugers Archiv : European journal of physiology 466:1301-16 PubMed24121765

2013

Dual depolarization responses generated within the same lateral septal neurons by TRPC4-containing channels.

Applications

Unspecified application

Species

Mouse

Jinbin Tian,Dhananjay P Thakur,Yungang Lu,Yingmin Zhu,Marc Freichel,Veit Flockerzi,Michael X Zhu

Nature neuroscience 13:1216-24 PubMed20852624

2010

Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95.

Applications

Unspecified application

Species

Unspecified reactive species

Jihoon Jo,Gi Hoon Son,Bryony L Winters,Myung Jong Kim,Daniel J Whitcomb,Bryony A Dickinson,Youn-Bok Lee,Kensuke Futai,Mascia Amici,Morgan Sheng,Graham L Collingridge,Kwangwook Cho

The Journal of neuroscience : the official journal of the Society for Neuroscience 30:5724-9 PubMed20410124

2010

Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Longhua Zhang,Bradley E Alger

PloS one 4:e6122 PubMed19568435

2009

Novel mGluR- and CB1R-independent suppression of GABA release caused by a contaminant of the group I metabotropic glutamate receptor agonist, DHPG.

Applications

Unspecified application

Species

Unspecified reactive species

Carlos A Lafourcade,Longhua Zhang,Bradley E Alger
View all publications
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