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MW 454.3 Da, Purity >98%. Irreversible, cell permeable broad-spectrum caspase inhibitor (IC50 values are 1.1 and 4.1 μM for caspase-3 and caspase-6 respectively). Inhibits hypoxia-induced apoptosis. Shows anti-ischemic effects in vivo. .

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Images

Chemical Structure - Z-Asp-CH2-DCB, caspase inhibitor (AB144607), expandable thumbnail

Key facts

CAS number
153088-73-4
Purity
> 98%
Molecular weight
454.3 Da
Molecular formula
C20H17Cl2NO7
PubChem identifier
9911778
Nature
Synthetic

Target data

Recommended products

MW 454.3 Da, Purity >98%. Irreversible, cell permeable broad-spectrum caspase inhibitor (IC50 values are 1.1 and 4.1 μM for caspase-3 and caspase-6 respectively). Inhibits hypoxia-induced apoptosis. Shows anti-ischemic effects in vivo. .

Key facts

Purity
> 98%
PubChem identifier
9911778
Solubility

Soluble in DMSO to 10 mM.

Biochemical name
Z-Asp-CH2-DCB
Biological description

Irreversible, cell permeable broad-spectrum caspase inhibitor (IC50 values are 1.1 and 4.1 μM for caspase-3 and caspase-6 respectively). Inhibits hypoxia-induced apoptosis. Shows anti-ischemic effects in vivo.

Canonical SMILES
C1=CC=C(C=C1)COC(=O)NC(CC(=O)O)C(=O)COC(=O)C2=C(C=CC=C2Cl)Cl
Isomeric SMILES
C1=CC=C(C=C1)COC(=O)N[C@@H](CC(=O)O)C(=O)COC(=O)C2=C(C=CC=C2Cl)Cl
InChI
InChI=1S/C20H17Cl2NO7/c21-13-7-4-8-14(22)18(13)19(27)29-11-16(24)15(9-17(25)26)23-20(28)30-10-12-5-2-1-3-6-12/h1-8,15H,9-11H2,(H,23,28)(H,25,26)/t15-/m0/s1
InChIKey
FKJMFCOMZYPWCO-HNNXBMFYSA-N
IUPAC name
(3S)-5-(2,6-dichlorobenzoyl)oxy-4-oxo-3-(phenylmethoxycarbonylamino)pentanoic acid

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

Product promise

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1 product image

  • Chemical Structure - Z-Asp-CH2-DCB, caspase inhibitor (ab144607), expandable thumbnail

    Chemical Structure - Z-Asp-CH2-DCB, caspase inhibitor (ab144607)

    2D chemical structure image of ab144607, Z-Asp-CH2-DCB, caspase inhibitor

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Product protocols

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