MW 668.7 Da, Purity >90%. Z-D(OMe)E(OMe)VD(OMe)-FMK, Cell permeable caspase-3 inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.
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- Journal of cellular biochemistry 120:19841-198572019Ethanolic extract of leaf of Dillenia pentagyna reduces in-vitro cell migration and induces intrinsic pathway of apoptosis via downregulation of NF-κβ in human NSCLC A549 cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDebapriya De,Priyanka Chowdhury,Sujogya K Panda,Utpal GhoshPubMed 31318086
- World journal of gastrointestinal oncology 11:377-3922019Qingjie Fuzheng granules inhibit colorectal cancer cell growth by the PI3K/AKT and ERK pathways.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHong Yang,Jian-Xin Liu,Hai-Xia Shang,Shan Lin,Jin-Yan Zhao,Jiu-Mao LinPubMed 31139308
- Neuroscience 136:579-912005Central administration of a caspase inhibitor impairs shuttle-box performance in rats.Applications:Unspecified applicationReactive species:Unspecified reactive speciesM Yu Stepanichev,I V Kudryashova,A A Yakovlev,M V Onufriev,L G Khaspekov,A A Lyzhin,N A Lazareva,N V GulyaevaPubMed 16198488
- Biological & pharmaceutical bulletin 23:930-52000Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesF Kugawa,A Ueno,M AokiPubMed 10963298
- The Journal of biological chemistry 273:28057-641998Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3.Applications:Unspecified applicationReactive species:Unspecified reactive speciesE Brockstedt,A Rickers,S Kostka,A Laubersheimer,B Dörken,B Wittmann-Liebold,K Bommert,A OttoPubMed 9774422
Key facts
- CAS number
210344-95-9
- Purity
> 90%
- Form
Solid
- Molecular weight
668.7 Da
- Molecular formula
C30H41FN4O12
- PubChem identifier
16760394
- Nature
Synthetic
Target data
Alternative names
A830040C14Rik, APOPAIN, CASP3_HUMAN, CC3, CPP-32, CPP32B, Casp3a, Caspase 3, apoptosis-related cysteine peptidase, Caspase 3, apoptosis-related cysteine protease, Caspase 3, apoptosis-related cysteine protease a, Caspase-3, Caspase-3 subunit p12, Cysteine protease CPP32, EC 3.4.22.56, ICE3, LICE, OTTHUMP00000165052, OTTHUMP00000165053, OTTHUMP00000165054, PARP cleavage protease, Procaspase3, Protein Yama, SCA-1, SREBP cleavage activity 1, Yama, Yama protein, mldy
Recommended products
MW 668.7 Da, Purity >90%. Z-D(OMe)E(OMe)VD(OMe)-FMK, Cell permeable caspase-3 inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.
Key facts
- CAS number
210344-95-9
- Purity
> 90%
- Form
Solid
- Molecular weight
668.7 Da
- Molecular formula
C30H41FN4O12
- PubChem identifier
16760394
- Nature
Synthetic
- Solubility
Soluble in DMSO to 20 mM.
- Biochemical name
Z-Devd-fmk
- Canonical SMILES
CC(C)C(C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CCC(=O)OC)NC(=O)C(CC(=O)OC)NC(=O)OCC1=CC=CC=C1
- Isomeric SMILES
CC(C)[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](CCC(=O)OC)NC(=O)[C@H](CC(=O)OC)NC(=O)OCC1=CC=CC=C1
- InChI
InChI=1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1
- InChIKey
GBJVAVGBSGRRKN-JYEBCORGSA-N
- IUPAC name
methyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-[[(2S)-4-methoxy-4-oxo-2-(phenylmethoxycarbonylamino)butanoyl]amino]-5-oxopentanoate
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
-20°C
- Appropriate long-term storage conditions
-20°C
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
Product promise
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
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2 product images
Chemical Structure - Z-D(OMe)E(OMe)VD(OMe)-FMK, Cell permeable caspase-3 inhibitor (ab120488)
2D chemical structure image of ab120488, Z-D(OMe)E(OMe)VD(OMe)-FMK, Cell permeable caspase-3 inhibitor
Functional Studies - Z-D(OMe)E(OMe)VD(OMe)-FMK, Cell permeable caspase-3 inhibitor (ab120488)
HeLa cells were incubated at 37 °C for 1h with vehicle control (0 μM) and different concentrations of Z-D(OMe)E(OMe)VD(OMe)-FMK (ab120488). After this incubation 10 μM of camptothecin (Camptothecin, DNA topoisomerase inhibitor ab120115) was added to all samples and the cells were incubated for further 24h. Increased expression of full length PARP (ab37722) in camptothecin induced apoptotic HeLA cells correlates with an increase in Z-D(OMe)E(OMe)VD(OMe)-FMK concentration, as described in literature.
Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 10 μg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 5% BSA before being incubated with ab37722 at 1 μg/ml and Anti-beta Actin antibody ab8227 at 1 μg /ml overnight at 4°C. Antibody binding was detected using an anti-rabbit antibody conjugated to HRP (Goat Anti-Rabbit IgG H&L (HRP) ab97051
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