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AB141382

Z-IETD-FMK, Caspase-8 inhibitor

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(8 Publications)

MW 654.7 Da, Purity >99%. Achieve your results faster with highly validated, pure and trusted compounds.
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Functional Studies - Z-IETD-FMK, Caspase-8 inhibitor (AB141382)
  • FuncS

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Functional Studies - Z-IETD-FMK, Caspase-8 inhibitor (AB141382)

ab13847 staining active caspase 3 in SKNSH cells treated with Z-IETD-FMK (ab141382), by ICC/IF. Decrease in active caspase 3 expression correlates with increased concentration of Z-IETD-FMK, as described in literature.
The cells were incubated at 37°C for 1 hour in media containing different concentrations of ab141382 (Z-IETD-FMK) in DMSO. After this incupation 10 µM of camptothecin (ab120115) was added to all samples and the cells were incubated for further 24 hours. The samples were then fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab13847 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DA

Chemical Structure - Z-IETD-FMK, Caspase-8 inhibitor (AB141382)
  • Chemical Structure

Lab

Chemical Structure - Z-IETD-FMK, Caspase-8 inhibitor (AB141382)

2D chemical structure image of ab141382, Z-IETD-FMK, Caspase-8 inhibitor

Key facts

CAS number

210344-98-2

Purity

>99%

Form

Lyophilized

form

Molecular weight

654.7 Da

Molecular formula

C<sub>3</sub><sub>0</sub>H<sub>4</sub><sub>3</sub>FN<sub>4</sub>O<sub>1</sub><sub>1</sub>

PubChem

44135212

Nature

Synthetic

Biochemical name

Caspase-8 inhibitor

Canonical smiles

CCC(C)C(C(=O)NC(CCC(=O)OC)C(=O)NC(C(C)O)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1

InChi

InChI=1S/C30H43FN4O11/c1-6-17(2)25(35-30(43)46-16-19-10-8-7-9-11-19)28(41)32-20(12-13-23(38)44-4)27(40)34-26(18(3)36)29(42)33-21(22(37)15-31)14-24(39)45-5/h7-11,17-18,20-21,25-26,36H,6,12-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,40)(H,35,43)

InChiKey

PHLCQASLWHYEMX-UHFFFAOYSA-N

IUPAC Name

methyl 5-[[1-[(5-fluoro-1-methoxy-1,4-dioxopentan-3-yl)amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-[[3-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-5-oxopentanoate

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Complementary Products

Biochemicals

AB141388

Z-YVAD-FMK, Irreversible caspase-1 inhibitor

Functional Studies - Z-YVAD-FMK, Irreversible caspase-1 inhibitor (AB141388)

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Biochemicals

AB120488

Z-D(OMe)E(OMe)VD(OMe)-FMK, Cell permeable caspase-3 inhibitor

Functional Studies - Z-D(OMe)E(OMe)VD(OMe)-FMK, Cell permeable caspase-3 inhibitor (AB120488)

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Biochemicals

AB120487

Z-VAD(OMe)-FMK, Cell permeable, irreversible pan-caspase inhibitor

Functional Studies - Z-VAD(OMe)-FMK, Cell permeable, irreversible pan-caspase inhibitor (AB120487)

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Biochemicals

AB141053

Necrostatin-1, necroptosis inhibitor

Functional Studies - Necrostatin-1, necroptosis inhibitor (AB141053)

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 1148 IETD-FMK, Z-,. 1148-5 is the same size as the 5 mg size of ab141382.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Translational andrology and urology 13:1405-1415 PubMed39280678

2024

External pressure induces the dysfunction of spermatogonia via triggering the intrinsic pathway of apoptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Yuxin Liu,Qihao Sun,Kun Du,Houtao Long,Daofeng Zhang,Junhao Zheng,Yong Zhao,Haiyang Zhang

Pharmaceutical biology 62:53-61 PubMed38108311

2023

Berberine decreases S100B generation to regulate gut vascular barrier permeability in mice with burn injury.

Applications

Unspecified application

Species

Unspecified reactive species

Aiwen Feng,Shaosheng Su,Cheng Li,Yutian Kang,Jiasheng Qiu,Jun Zhou

Scientific reports 12:12317 PubMed35853963

2022

Direct cleavage of caspase-8 by herpes simplex virus 1 tegument protein US11.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Musarra-Pizzo,Rosamaria Pennisi,Daniele Lombardo,Tania Velletri,Maria Teresa Sciortino

Frontiers in microbiology 12:654709 PubMed34484133

2021

SARS-CoV-2 Accessory Protein ORF7b Mediates Tumor Necrosis Factor-α-Induced Apoptosis in Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ruiping Yang,Qiong Zhao,Jingjing Rao,Feng Zeng,Shengren Yuan,Manshan Ji,Xiaoguang Sun,Jian Li,Jing Yang,Jingwen Cui,Zhixiong Jin,Long Liu,Zhixin Liu

Redox biology 30:101415 PubMed31901590

2020

Fundc1-dependent mitophagy is obligatory to ischemic preconditioning-conferred renoprotection in ischemic AKI via suppression of Drp1-mediated mitochondrial fission.

Applications

Unspecified application

Species

Unspecified reactive species

Jin Wang,Pingjun Zhu,Ruibing Li,Jun Ren,Hao Zhou

World journal of gastrointestinal oncology 11:377-392 PubMed31139308

2019

Qingjie Fuzheng granules inhibit colorectal cancer cell growth by the PI3K/AKT and ERK pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Hong Yang,Jian-Xin Liu,Hai-Xia Shang,Shan Lin,Jin-Yan Zhao,Jiu-Mao Lin

Scientific reports 7:977 PubMed28428545

2017

Beclin-1-mediated Autophagy Protects Against Cadmium-activated Apoptosis via the Fas/FasL Pathway in Primary Rat Proximal Tubular Cell Culture.

Applications

Unspecified application

Species

Unspecified reactive species

Gang Liu,Yan Yuan,Mengfei Long,Tongwang Luo,Jianchun Bian,Xuezhong Liu,Jianhong Gu,Hui Zou,Ruilong Song,Yi Wang,Lin Wang,Zongping Liu

Prostate cancer and prostatic diseases 19:358-366 PubMed27431500

2016

Berbamine inhibited the growth of prostate cancer cells in vivo and in vitro via triggering intrinsic pathway of apoptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Y Zhao,J J Lv,J Chen,X B Jin,M W Wang,Z H Su,L Y Wang,H Y Zhang
View all publications
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