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MW 654.7 Da, Purity >99%. Z-IETD-FMK, Caspase-8 inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.

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Images

Chemical Structure - Z-IETD-FMK, Caspase-8 inhibitor (AB141382), expandable thumbnail
  • Functional Studies - Z-IETD-FMK, Caspase-8 inhibitor (AB141382), expandable thumbnail

Publications

Key facts

CAS number

210344-98-2

Purity

> 99%

Form

Lyophilized

Molecular weight

654.7 Da

Molecular formula

C30H43FN4O11

PubChem identifier

44135212

Nature

Synthetic

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MW 654.7 Da, Purity >99%. Z-IETD-FMK, Caspase-8 inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.

Key facts

Purity

> 99%

PubChem identifier

44135212

Biochemical name

Caspase-8 inhibitor

Canonical SMILES

CCC(C)C(C(=O)NC(CCC(=O)OC)C(=O)NC(C(C)O)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1

InChI

InChI=1S/C30H43FN4O11/c1-6-17(2)25(35-30(43)46-16-19-10-8-7-9-11-19)28(41)32-20(12-13-23(38)44-4)27(40)34-26(18(3)36)29(42)33-21(22(37)15-31)14-24(39)45-5/h7-11,17-18,20-21,25-26,36H,6,12-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,40)(H,35,43)

InChIKey

PHLCQASLWHYEMX-UHFFFAOYSA-N

IUPAC name

methyl 5-[[1-[(5-fluoro-1-methoxy-1,4-dioxopentan-3-yl)amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-[[3-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-5-oxopentanoate

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Storage information

Store under desiccating conditions, The product can be stored for up to 12 months

Notes

This product is manufactured by BioVision, an Abcam company and was previously called 1148 IETD-FMK, Z-,. 1148-5 is the same size as the 5 mg size of ab141382.

Product promise

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2 product images

  • Chemical Structure - Z-IETD-FMK, Caspase-8 inhibitor (ab141382), expandable thumbnail

    Chemical Structure - Z-IETD-FMK, Caspase-8 inhibitor (ab141382)

    2D chemical structure image of ab141382, Z-IETD-FMK, Caspase-8 inhibitor

  • Functional Studies - Z-IETD-FMK, Caspase-8 inhibitor (ab141382), expandable thumbnail

    Functional Studies - Z-IETD-FMK, Caspase-8 inhibitor (ab141382)

    Anti-Caspase-3 antibody ab13847 staining active caspase 3 in SKNSH cells treated with Z-IETD-FMK (ab141382), by ICC/IF. Decrease in active caspase 3 expression correlates with increased concentration of Z-IETD-FMK, as described in literature.
    The cells were incubated at 37°C for 1 hour in media containing different concentrations of ab141382 (Z-IETD-FMK) in DMSO. After this incupation 10 µM of camptothecin (Camptothecin, DNA topoisomerase inhibitor ab120115) was added to all samples and the cells were incubated for further 24 hours. The samples were then fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with Anti-Caspase-3 antibody ab13847 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DA

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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