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AB142026

Z-LEHD-FMK, caspase-9 inhibitor

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(5 Publications)

MW 690.7 Da, Purity >98%. Achieve your results faster with highly validated, pure and trusted compounds.
3 Images
Functional Studies (Act) - Z-LEHD-FMK, caspase-9 inhibitor (AB142026)
  • FuncS (Act)

Unknown

Functional Studies (Act) - Z-LEHD-FMK, caspase-9 inhibitor (AB142026)

Differentiated muscle cells were pre-incubated with 20 μM Z-LEHD-FMK (irreversible caspas-9 inhibitor) for 30 min before exposure to anoxic conditions. C) Light microscopy pictures demonstrates morphological changes during anoxia treatment. Arrows indicate rounded up, dead cells. D) Live/dead analysis demonstrate increased number of dead cells during 6 h anoxia, but this is unaffected by the irreversible caspase-9 inhibitor.

Image from Beate Ronning S, et al. Plos One, 12(8), e0182928. Fig 6C and D,; doi: 10.1371/journal.pone.0182928

Functional Studies - Z-LEHD-FMK, caspase-9 inhibitor (AB142026)
  • FuncS

Lab

Functional Studies - Z-LEHD-FMK, caspase-9 inhibitor (AB142026)

Functional assays : Caspase 9 Inhibitor Drug Detection Kit (ab102497)

Titration of the caspase 9 inhibitor Z-LEHD-FMK (ab142026) (duplicates; +/- SD).

Chemical Structure - Z-LEHD-FMK, caspase-9 inhibitor (AB142026)
  • Chemical Structure

Lab

Chemical Structure - Z-LEHD-FMK, caspase-9 inhibitor (AB142026)

2D chemical structure image of ab142026, Z-LEHD-FMK, caspase-9 inhibitor

Key facts

CAS number

210345-04-3

Purity

>98%

Form

Liquid

form

Molecular weight

690.7 Da

Molecular formula

C<sub>3</sub><sub>2</sub>H<sub>4</sub><sub>3</sub>FN<sub>6</sub>O<sub>1</sub><sub>0</sub>

PubChem

44135217

Nature

Synthetic

Biochemical name

Cbz-DL-Leu-DL-Glu(OMe)-DL-His-DL-Asp(OMe)-CH2F

Canonical smiles

CC(C)CC(C(=O)NC(CCC(=O)OC)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC2=CC=CC=C2

InChi

InChI=1S/C32H43FN6O10/c1-19(2)12-24(39-32(46)49-17-20-8-6-5-7-9-20)30(44)36-22(10-11-27(41)47-3)29(43)38-25(13-21-16-34-18-35-21)31(45)37-23(26(40)15-33)14-28(42)48-4/h5-9,16,18-19,22-25H,10-15,17H2,1-4H3,(H,34,35)(H,36,44)(H,37,45)(H,38,43)(H,39,46)

InChiKey

YXRKBEPGVHOXSV-UHFFFAOYSA-N

IUPAC Name

methyl 5-[[1-[(5-fluoro-1-methoxy-1,4-dioxopentan-3-yl)amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-4-[[4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-5-oxopentanoate

10 mM
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Biochemicals

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 1074 Caspase-9 Inhibitor Z-LEHD-FMK. 1074-20C is the same size as the 20 µl size of ab142026.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Refer to SDS for further information.

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Product protocols

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Autophagy 19:551-569 PubMed35670302

2022

The ORF7a protein of SARS-CoV-2 initiates autophagy and limits autophagosome-lysosome fusion via degradation of SNAP29 to promote virus replication.

Applications

Unspecified application

Species

Unspecified reactive species

Peili Hou,Xuefeng Wang,Hongmei Wang,Tiecheng Wang,Zhangping Yu,Chunqing Xu,Yudong Zhao,Wenqi Wang,Yong Zhao,Fengyun Chu,Huasong Chang,Hongchao Zhu,Jiahui Lu,Fuzhen Zhang,Xue Liang,Xingyu Li,Song Wang,Yuwei Gao,Hongbin He

Nature microbiology 5:1119-1133 PubMed32514074

2020

Spatiotemporal proteomics uncovers cathepsin-dependent macrophage cell death during Salmonella infection.

Applications

Unspecified application

Species

Unspecified reactive species

Joel Selkrig,Nan Li,Annika Hausmann,Matthew S J Mangan,Matylda Zietek,André Mateus,Jacob Bobonis,Anna Sueki,Haruna Imamura,Bachir El Debs,Gianluca Sigismondo,Bogdan I Florea,Herman S Overkleeft,Nataša Kopitar-Jerala,Boris Turk,Pedro Beltrao,Mikhail M Savitski,Eicke Latz,Wolf-Dietrich Hardt,Jeroen Krijgsveld,Athanasios Typas

World journal of gastrointestinal oncology 11:377-392 PubMed31139308

2019

Qingjie Fuzheng granules inhibit colorectal cancer cell growth by the PI3K/AKT and ERK pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Hong Yang,Jian-Xin Liu,Hai-Xia Shang,Shan Lin,Jin-Yan Zhao,Jiu-Mao Lin

PloS one 12:e0182928 PubMed28792534

2017

Primary bovine skeletal muscle cells enters apoptosis rapidly via the intrinsic pathway when available oxygen is removed.

Applications

Unspecified application

Species

Unspecified reactive species

Sissel Beate Rønning,Petter Vejle Andersen,Mona Elisabeth Pedersen,Kristin Hollung

World journal of gastroenterology 22:6509-19 PubMed27605885

2016

c-Jun N-terminal kinase-mediated Rubicon expression enhances hepatocyte lipoapoptosis and promotes hepatocyte ballooning.

Applications

Unspecified application

Species

Unspecified reactive species

Akiko Suzuki,Keisuke Kakisaka,Yuji Suzuki,Ting Wang,Yasuhiro Takikawa
View all publications
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