MW 652.7 Da, Purity >98%. Z-VEID-FMK, caspase-6 inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.
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- Viruses 13:2021Inhibitors of Venezuelan Equine Encephalitis Virus Identified Based on Host Interaction Partners of Viral Non-Structural Protein 3.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAllison Bakovic,Nishank Bhalla,Farhang Alem,Catherine Campbell,Weidong Zhou,Aarthi NarayananPubMed 34452398
Key facts
- CAS number
- 210344-96-0
- Purity
- > 98%
- Form
- Liquid
- Molecular weight
- 652.7 Da
- Molecular formula
- C31H45FN4O10
- PubChem identifier
- 44135214
- Nature
- Synthetic
Recommended products
MW 652.7 Da, Purity >98%. Z-VEID-FMK, caspase-6 inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.
Key facts
- CAS number
- 210344-96-0
- Purity
- > 98%
- Form
- Liquid
- Molecular weight
- 652.7 Da
- Molecular formula
- C31H45FN4O10
- PubChem identifier
- 44135214
- Nature
- Synthetic
- Biochemical name
- Z-Veid-fmk
- Canonical SMILES
- CCC(C)C(C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CCC(=O)OC)NC(=O)C(C(C)C)NC(=O)OCC1=CC=CC=C1
- InChI
- InChI=1S/C31H45FN4O10/c1-7-19(4)27(30(42)34-22(23(37)16-32)15-25(39)45-6)35-28(40)21(13-14-24(38)44-5)33-29(41)26(18(2)3)36-31(43)46-17-20-11-9-8-10-12-20/h8-12,18-19,21-22,26-27H,7,13-17H2,1-6H3,(H,33,41)(H,34,42)(H,35,40)(H,36,43)
- InChIKey
- YPIHFMWAHMPACV-UHFFFAOYSA-N
- IUPAC name
- methyl 5-[[1-[(5-fluoro-1-methoxy-1,4-dioxopentan-3-yl)amino]-3-methyl-1-oxopentan-2-yl]amino]-4-[[3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]-5-oxopentanoate
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions
Notes
This product is manufactured by BioVision, an Abcam company and was previously called 1011 Caspase-6 Inhibitor Z-VEID-FMK. 1011-20C is the same size as the 20 μl size of ab142025.
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2 product images
Chemical Structure - Z-VEID-FMK, caspase-6 inhibitor (ab142025)
2D chemical structure image of ab142025, Z-VEID-FMK, caspase-6 inhibitor
Functional Studies - Z-VEID-FMK, caspase-6 inhibitor (ab142025)
SHSY5Y cells were incubated at 37 °C for 1h with vehicle control (0 μM) and 1 μM of Z-VEID-FMK (ab142025). After this incubation 10µM of camptothecin (Camptothecin, DNA topoisomerase inhibitor ab120115) was added to all samples and the cells were incubated for further 24h. Increased expression of full length PARP (ab37722) in camptothecin induced apoptotic SHSY5Y cells correlates with an increase in Z-VEID-FMK concentration, as described in literature.
Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 20 μg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 3% milk before being incubated with ab37722 at 1 μg/ml and Anti-beta Actin antibody ab8227 at 1 μg/ml overnight at 4°C. Antibody binding was detected using an anti-rabbit antibody conjugated to HRP (Goat Anti-Rabbit IgG H&L (HRP) ab97051) at 1/10000 dilution and visualised using ECL development solution.
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