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AB120940

Zaprinast, cGMP phosphodiesterase inhibitor

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MW 271.28 g/mol, Purity >98%. Specific cGMP phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC50 values are 0.15 (PDE6), 0.76 (PDE5), 12 (PDE11) and 29 μM (PDE9)). Reputed GPR35 agonist (EC50 values are 16 and 840 nM at rat and human GPR35 receptors, respectively). Important mediator for a variety of cellular processes including vasodilation.
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Functional Studies - Zaprinast, cGMP phosphodiesterase inhibitor (AB120940)
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Functional Studies - Zaprinast, cGMP phosphodiesterase inhibitor (AB120940)

ab76165 staining ERK1 + ERK2 (phospho T202 + Y204) in U87MG cells treated with zaprinast (ab120940), by ICC/IF. Increase of ERK1 + ERK2 (phospho T202 + Y204) expression correlates with increased concentration of zaprinast, as described in literature.
The cells were incubated at 37°C for 24 hours in media containing different concentrations of ab120940 (zaprinast) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab76165 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Zaprinast, cGMP phosphodiesterase inhibitor (AB120940)
  • Chemical Structure

Lab

Chemical Structure - Zaprinast, cGMP phosphodiesterase inhibitor (AB120940)

2D chemical structure image of ab120940, Zaprinast, cGMP phosphodiesterase inhibitor

Key facts

CAS number

37762-06-4

Purity

>98%

Form

Solid

form

Molecular weight

271.28 g/mol

Molecular formula

C<sub>1</sub><sub>3</sub>H<sub>1</sub><sub>3</sub>N<sub>5</sub>O<sub>2</sub>

Nature

Synthetic

Solubility

Soluble in DMSO to 25 mM

Biological description

Specific cGMP phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC50 values are 0.15 (PDE6), 0.76 (PDE5), 12 (PDE11) and 29 μM (PDE9)). Reputed GPR35 agonist (EC50 values are 16 and 840 nM at rat and human GPR35 receptors, respectively). Important mediator for a variety of cellular processes including vasodilation.

Canonical smiles

CCCOC1CCCCC1C1[NH]C(=O)C2NN[NH]C2N1

IUPAC Name

3,6-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-one

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Biochemicals

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Chemical Structure - NECA, adenosine agonist (AB120440)

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Biochemicals

AB120029

(R,S)-Rolipram, Selective PDE4 inhibitor

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Biochemicals

AB120451

Dipyridamole, Non-selective phosphodiesterase (PDE) inhibitor

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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