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AB147489

ZD7288 (Aqueous Solution)

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(4 Publications)

MW 292.81 Da. Sino-atrial node function modulator; blocks the hyperpolarisation activated inward current If. Also inhibits Ih in central neurons and inhibits synaptic transmission.

Key facts

CAS number

133059-99-1

Form

Liquid

form

Molecular weight

292.81 Da

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>2</sub><sub>1</sub>ClN<sub>4</sub>

PubChem

123983

Nature

Synthetic

Biochemical name

4-(N-Ethyl-N-phenylamino)-1,2-dimethyl-6-(methylamino)pyrimidinium chloride

Biological description

Sino-atrial node function modulator; blocks the hyperpolarisation activated inward current If. Also inhibits Ih in central neurons and inhibits synaptic transmission.

Canonical smiles

CCN(C1=CC=CC=C1)C2=CC(=NC)N(C(=N2)C)C.Cl

InChi

InChI=1S/C15H20N4.ClH/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;/h6-11H,5H2,1-4H3;1H

InChiKey

DUWKUHWHTPRMAP-UHFFFAOYSA-N

IUPAC Name

N-ethyl-1,2-dimethyl-6-methylimino-N-phenylpyrimidin-4-amine;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
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Product protocols

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:9887 PubMed39543166

2024

Histamine-tuned subicular circuit mediates alert-driven accelerated locomotion in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Yang,Mengdi Zhang,Yuan Zhou,Dongxiao Jiang,Lilong Yu,Lingyu Xu,Fan Fei,Wenkai Lin,Yanrong Zheng,Jiannong Wu,Yi Wang,Zhong Chen

Current biology : CB 28:3911-3923.e2 PubMed30503615

2018

Control of Xenopus Tadpole Locomotion via Selective Expression of Ih in Excitatory Interneurons.

Applications

Unspecified application

Species

Unspecified reactive species

Laurence D Picton,Keith T Sillar,Hong-Yan Zhang

Molecular psychiatry 23:892-903 PubMed28416809

2017

Perisomatic changes in h-channels regulate depressive behaviors following chronic unpredictable stress.

Applications

Unspecified application

Species

Unspecified reactive species

C S Kim,D H Brager,D Johnston

Journal of neurophysiology 116:438-47 PubMed27146984

2016

HCN hyperpolarization-activated cation channels strengthen virtual nicotinic EPSPs and thereby elevate synaptic amplification in rat sympathetic neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Paul H M Kullmann,Kristine M Sikora,K Lyles Clark,Irene Arduini,Mitchell G Springer,John P Horn
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