MW 292.81 Da, Purity >98%. Sino-atrial node function modulator; blocks the hyperpolarisation activated inward current If. Also inhibits Ih in central neurons and inhibits synaptic transmission.
Images
Publications
Filter by
- Proceedings of the National Academy of Sciences of the United States of America 120:e22070031202023Histamine H receptor deficit in glutamatergic neurons contributes to the pathogenesis of schizophrenia.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQianyi Ma,Lei Jiang,Han Chen,Dadao An,Yiting Ping,Yujia Wang,Haibin Dai,Xiangnan Zhang,Yi Wang,Zhong Chen,Weiwei HuPubMed 36812204
- Nature communications 13:50102022Discrete subicular circuits control generalization of hippocampal seizures.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFan Fei,Xia Wang,Cenglin Xu,Jiaying Shi,Yiwei Gong,Heming Cheng,Nanxi Lai,Yeping Ruan,Yao Ding,Shuang Wang,Zhong Chen,Yi WangPubMed 36008421
- iScience 25:1039222022Conjunctive changes in multiple ion channels mediate activity-dependent intrinsic plasticity in hippocampal granule cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPoonam Mishra,Rishikesh NarayananPubMed 35252816
- Neuron 110:644-657.e62022A novel reticular node in the brainstem synchronizes neonatal mouse crying with breathing.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXin Paul Wei,Matthew Collie,Bowen Dempsey,Gilles Fortin,Kevin YacklePubMed 34998469
- Cell reports 36:1094952021Severe deficiency of the voltage-gated sodium channel Na1.2 elevates neuronal excitability in adult mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJingliang Zhang,Xiaoling Chen,Muriel Eaton,Jiaxiang Wu,Zhixiong Ma,Shirong Lai,Anthony Park,Talha S Ahmad,Zhefu Que,Ji Hea Lee,Tiange Xiao,Yuansong Li,Yujia Wang,Maria I Olivero-Acosta,James A Schaber,Krishna Jayant,Chongli Yuan,Zhuo Huang,Nadia A Lanman,William C Skarnes,Yang YangPubMed 34348148
- Current biology : CB 28:3911-3923.e22018Control of Xenopus Tadpole Locomotion via Selective Expression of Ih in Excitatory Interneurons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLaurence D Picton et. al.PubMed 30503615
- Molecular psychiatry 23:892-9032017Perisomatic changes in h-channels regulate depressive behaviors following chronic unpredictable stress.Applications:Unspecified applicationReactive species:Unspecified reactive speciesC S Kim,D H Brager,D JohnstonPubMed 28416809
- Journal of neurophysiology 116:438-472016HCN hyperpolarization-activated cation channels strengthen virtual nicotinic EPSPs and thereby elevate synaptic amplification in rat sympathetic neurons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPaul H M Kullmann et. al.PubMed 27146984
- British journal of pharmacology 172:3126-402015Thalamic Kv 7 channels: pharmacological properties and activity control during noxious signal processing.Applications:Unspecified applicationReactive species:Unspecified reactive speciesManuela Cerina et. al.PubMed 25684311
- The Journal of neuroscience : the official journal of the Society for Neuroscience 35:4025-392015Extracellular pH regulates excitability of vomeronasal sensory neurons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAnnika Cichy,Tobias Ackels,Chryssanthi Tsitoura,Anat Kahan,Nina Gronloh,Melanie Söchtig,Corinna H Engelhardt,Yoram Ben-Shaul,Frank Müller,Jennifer Spehr,Marc SpehrPubMed 25740530
Key facts
- CAS number
- 133059-99-1
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 292.81 Da
- Molecular formula
- C15H21ClN4
- PubChem identifier
- 123983
- Nature
- Synthetic
Associated Products
Select an associated product type
1 product for Alternative Product
Target data
Recommended products
MW 292.81 Da, Purity >98%. Sino-atrial node function modulator; blocks the hyperpolarisation activated inward current If. Also inhibits Ih in central neurons and inhibits synaptic transmission.
Key facts
- CAS number
- 133059-99-1
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 292.81 Da
- Molecular formula
- C15H21ClN4
- PubChem identifier
- 123983
- Nature
- Synthetic
- Solubility
Soluble in water to 100 mM.
- Biochemical name
- 4-(N-Ethyl-N-phenylamino)-1,2-dimethyl-6-(methylamino)pyrimidinium chloride
- Biological description
Sino-atrial node function modulator; blocks the hyperpolarisation activated inward current If. Also inhibits Ih in central neurons and inhibits synaptic transmission.
- Canonical SMILES
- CCN(C1=CC=CC=C1)C2=CC(=NC)N(C(=N2)C)C.Cl
- InChI
- InChI=1S/C15H20N4.ClH/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;/h6-11H,5H2,1-4H3;1H
- InChIKey
- DUWKUHWHTPRMAP-UHFFFAOYSA-N
- IUPAC name
- N-ethyl-1,2-dimethyl-6-methylimino-N-phenylpyrimidin-4-amine;hydrochloride
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
2 product images
Chemical Structure - ZD7288, Sino-atrial node function modulator (ab120102)
2D chemical structure image of ab120102, ZD7288, Sino-atrial node function modulator
Image from Glasgow D, et al. Plos One, 8(3), e58901. Fig 6B,; doi: 10.1371/journal.pone.0058901Cellular Activation - ZD7288, Sino-atrial node function modulator (ab120102)
Membrane currents during slow voltage ramps from ?120 mV to ?40 mV in the presence of TTX (0.5 μM) and ZD7288 (50 μM), and during subsequent bath application of CCh (light grey line; 50 μM; B1) show that cholinergic receptor activation induces an inward current at voltages near resting membrane potential that reverses around ?76 mV, consistent the blockade of outward K+ currents. The application of CCh occluded additional inward current during subsequent bath application of XE-991 (dark grey line; 10 μM) sμggesting that CCh depolarizes PaS neurons in part by suppression of the M-current. Current subtractions show that CCh blocks an outward current that reverses at ?83.3±7.0 mV (black line; B2), and also occluded membrane currents normally induced by XE-991 (grey line).
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com