ZD7288, Sino-atrial node function modulator

• Chemical Structure

Lab

Chemical Structure - ZD7288, Sino-atrial node function modulator (AB120102)

2D chemical structure image of ab120102, ZD7288, Sino-atrial node function modulator

• CellAct

Unknown

Cellular Activation - ZD7288, Sino-atrial node function modulator (AB120102)

Membrane currents during slow voltage ramps from -120 mV to -40 mV in the presence of TTX (0.5 μM) and ZD7288 (50 μM), and during subsequent bath application of CCh (light grey line; 50 μM; B1) show that cholinergic receptor activation induces an inward current at voltages near resting membrane potential that reverses around -76 mV, consistent the blockade of outward K+ currents. The application of CCh occluded additional inward current during subsequent bath application of XE-991 (dark grey line; 10 μM) sμggesting that CCh depolarizes PaS neurons in part by suppression of the M-current. Current subtractions show that CCh blocks an outward current that reverses at -83.3±7.0 mV (black line; B2), and also occluded membrane currents normally induced by XE-991 (grey line).

Image from Glasgow D, et al. Plos One, 8(3), e58901. Fig 6B,; doi: 10.1371/journal.pone.0058901