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AB120428

ZM 336372, c-Raf inhibitor

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MW 389.4 Da, Purity >98%. Potent, cell-permeable and selective c-Raf inhibitor (IC50 = 70 nM). Displays 10-fold selectivity over b-Raf. Inhibits carcinoid cell growth. Also inhibits growth and apoptosis in pancreatic cancer cells.
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Chemical Structure - ZM 336372, c-Raf inhibitor (AB120428)
  • Chemical Structure

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Chemical Structure - ZM 336372, c-Raf inhibitor (AB120428)

2D chemical structure image of ab120428, ZM 336372, c-Raf inhibitor

Key facts

CAS number

208260-29-1

Purity

>98%

Form

Solid

form

Molecular weight

389.4 Da

Molecular formula

C<sub>2</sub><sub>3</sub>H<sub>2</sub><sub>3</sub>N<sub>3</sub>O<sub>3</sub>

PubChem

5730

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

3-(dimethylamino)-N-(3-(4-hydroxybenzamido)-4-methylphenyl)benzamide

Biological description

Potent, cell-permeable and selective c-Raf inhibitor (IC50 = 70 nM). Displays 10-fold selectivity over b-Raf. Inhibits carcinoid cell growth. Also inhibits growth and apoptosis in pancreatic cancer cells.

Canonical smiles

CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)N(C)C)NC(=O)C3=CC=C(C=C3)O

InChi

InChI=1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28)

InChiKey

PYEFPDQFAZNXLI-UHFFFAOYSA-N

IUPAC Name

3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]benzamide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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