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MW 513.6 Da, Purity >98%. ZM 447439, Aurora B kinase inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.

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Key facts

CAS number
331771-20-1
Purity
> 98%
Molecular weight
513.6 Da
Molecular formula
C29H31N5O4
PubChem identifier
9914412
Nature
Synthetic

Target data

Alternative names

AI838772, AIK, AIK2, ARK-1, ARK-2, AURA, AURKB_HUMAN, AURORA/IPL1-like kinase, AW493413, AurB, Aurora 1, Aurora 2, Aurora A, Aurora kinase A, Aurora kinase B, Aurora- and Ipl1-like midbody-associated protein 1, Aurora-B, Aurora-related kinase 1, Aurora-related kinase 2, Aurora/IPL1-related kinase 1, Aurora/IPL1-related kinase 2, Avian erythroblastic leukemia viral (v erb b) oncogene homolog, BTAK, Breast tumor-amplified kinase, Cell growth inhibiting protein 40, Cell proliferation inducing protein 61, EGFR_HUMAN, ERBB, ERBB1, Epidermal growth factor receptor, Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog), Epidermal growth factor receptor (erythroblastic leukemia viral (v erb b) oncogene homolog avian), Errp, FLJ11090, HER1, IAK, IPL1, IPL1 related kinase, MGC104252, MGC112732, MGC34538, NISBD2, OTTHUMP00000031340, OTTHUMP00000031341, OTTHUMP00000031342, OTTHUMP00000031343, OTTHUMP00000031344, OTTHUMP00000031345, OTTHUMP00000166071, OTTHUMP00000166072, Oncogen ERBB, PIG61, PPP1R47, PPP1R48, Protein phosphatase 1 regulatory subunit 48, Protein phosphatase 1, regulatory subunit 47, Proto-oncogene c-ErbB-1, RP24-311F12.2, Receptor tyrosine-protein kinase ErbB-1, SA7, SCAN1, STK-1, STK12, STK15, STK5, STK6, STK6_HUMAN, STK7, Serine/theronine kinase 12, Serine/threonine kinase 15, Serine/threonine kinase 6, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase aurora-A, Serine/threonine-protein kinase aurora-B, Species antigen 7, TYDP, TYDP1_HUMAN, Tyr-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, Urogastrone, Wa5, erb-b2 receptor tyrosine kinase 1, hARK1, mENA, v-erb-b Avian erythroblastic leukemia viral oncogen homolog, wa2

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MW 513.6 Da, Purity >98%. ZM 447439, Aurora B kinase inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.

Key facts

Purity
> 98%
PubChem identifier
9914412
Solubility

Soluble in DMSO to 100 mM.

Biochemical name
N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide
Canonical SMILES
COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)NC(=O)C4=CC=CC=C4)OCCCN5CCOCC5
InChI
InChI=1S/C29H31N5O4/c1-36-26-18-24-25(19-27(26)38-15-5-12-34-13-16-37-17-14-34)30-20-31-28(24)32-22-8-10-23(11-9-22)33-29(35)21-6-3-2-4-7-21/h2-4,6-11,18-20H,5,12-17H2,1H3,(H,33,35)(H,30,31,32)
InChIKey
OGNYUTNQZVRGMN-UHFFFAOYSA-N
IUPAC name
N-[4-[[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino]phenyl]benzamide

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

EGFR (Epidermal Growth Factor Receptor) also known as HER1 or ErbB1 mechanically functions as a cell surface receptor for members of the epidermal growth factor family. It possesses kinase activity and plays role in signal transduction processes that regulate cell proliferation and survival. EGFR forms dimer complexes when activated which initiates a cascade of downstream signaling pathways. It has a molecular mass of around 170 kDa and expresses widely in epithelial tissues including the skin lung and colorectal regions.

Biological function summary

Aurora kinases A and B are essential part of cellular division. Aurora A primarily localizes to the centrosomes and spindle microtubules whereas Aurora B is a component of the chromosomal passenger complex (CPC) aiding in accurate chromosome segregation and cytokinesis. TDP1 (Tyrosyl-DNA Phosphodiesterase 1) functions in the repair of DNA double-strand breaks. These proteins work collectively in maintaining genomic stability ensuring correct cellular replication and repair.

Pathways

EGFR activity links to the MAPK and PI3K/AKT pathways influencing cell cycle progression and survival. Aurora kinases interact with proteins such as PLK1 and Cyclin B in the mitotic pathway coordinating timing and structure of cell division. TDP1 operates in DNA repair pathways alongside proteins like XRCC1 repairing covalent DNA-protein complexes contributing to cellular resistance to certain chemotherapeutic agents.

Associated diseases and disorders

EGFR overexpression or mutation often associates with various cancers including non-small cell lung cancer and colorectal cancer through persistent activation of downstream signaling pathways. Aurora kinases become overactive in different tumor types contributing to aneuploidy and malignant transformation. TDP1 associates with neurodegenerative disorders like spinocerebellar ataxia and has implications in cancer especially in cancers that utilize topoisomerase I inhibitors for treatment relating closely with DNA repair proteins.

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