Zoledronic acid, FPP synthase inhibitor

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(2 Publications)

MW 272.09 Da, Purity >98%. Highly potent bisphosphonate. FPP synthase inhibitor. Inhibits osteoclastogenesis (IC₅₀ = 15 nM). Inhibits ASM and FDPS. Activates PKC. Inhibits osteoclastic bone resorption, shows antihypocalcemic and antiangiogenic effects in vivo. .

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(2E,6E) farnesyl diphosphate synthase, 6E)-farnesyl diphosphate synthase, BT3A1_HUMAN, Butyrophilin subfamily 3 member A1, CA 12, CA 14, CA 2, CA-II, CA-XII, CA-XIV, CAC, CAH12_HUMAN, CAH14_HUMAN, CAH2_HUMAN, CD277, Car 2, Carbonate dehydratase II, Carbonate dehydratase XII, Carbonate dehydratase XIV, Carbonic anhydrase 12, Carbonic anhydrase 14, Carbonic anhydrase 2, Carbonic anhydrase B, Carbonic anhydrase C, Carbonic anhydrase C, formerly, Carbonic anhydrase II, Carbonic anhydrase XII, Carbonic anhydrase XIV, Carbonic dehydratase, Dimethylallyltranstransferase, Epididymis secretory protein Li 282, FLJ20151, FPP synthase, FPP synthetase, FPPS_HUMAN, FPS, Farnesyl diphosphate synthase, Farnesyl diphosphate synthetase, Farnesyl pyrophosphate synthase, Farnesyl pyrophosphate synthetase, Fdps, Geranyltranstransferase, HEL-76, HEL-S-282, HsT18816, T18816, Tumor antigen HOM-RCC-3.1.3, UNQ690/PRO1335, epididymis luminal protein 76