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AB141980

Zoledronic acid, FPP synthase inhibitor

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(2 Publications)

MW 272.09 Da, Purity >98%. Highly potent bisphosphonate. FPP synthase inhibitor. Inhibits osteoclastogenesis (IC50 = 15 nM). Inhibits ASM and FDPS. Activates PKC. Inhibits osteoclastic bone resorption, shows antihypocalcemic and antiangiogenic effects in vivo. .
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Chemical Structure - Zoledronic acid, FPP synthase inhibitor (AB141980)
  • Chemical Structure

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Chemical Structure - Zoledronic acid, FPP synthase inhibitor (AB141980)

2D chemical structure image of ab141980, Zoledronic acid, FPP synthase inhibitor

Key facts

CAS number

118072-93-8

Purity

>98%

Form

Solid

form

Molecular weight

272.09 Da

Molecular formula

C<sub>5</sub>H<sub>1</sub><sub>0</sub>N<sub>2</sub>O<sub>7</sub>P<sub>2</sub>

PubChem

68740

Nature

Synthetic

Solubility

Soluble in water (up to 2 mg/ml)

Biochemical name

Zoledronic acid

Biological description

Highly potent bisphosphonate. FPP synthase inhibitor. Inhibits osteoclastogenesis (IC50 = 15 nM). Inhibits ASM and FDPS. Activates PKC. Inhibits osteoclastic bone resorption, shows antihypocalcemic and antiangiogenic effects in vivo.

Canonical smiles

C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O

InChi

InChI=1S/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14)

InChiKey

XRASPMIURGNCCH-UHFFFAOYSA-N

IUPAC Name

(1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid

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Complementary Products

Biochemicals

AB145867

Licarbazepine (10,11-Dihydro-10-hydroxycarbamazepine), Active oxcarbazepine metabolite

Chemical Structure - Licarbazepine (10,11-Dihydro-10-hydroxycarbamazepine), Active oxcarbazepine metabolite (AB145867)

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Biochemicals

AB143738

Zoledronate disodium salt, bisphosphonate bone resorption inhibitor

Chemical Structure - Zoledronate disodium salt, bisphosphonate bone resorption inhibitor (AB143738)

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Primary Antibodies

AB221547

Anti-ZO1 tight junction protein antibody [EPR19945-296]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZO1 tight junction protein antibody [EPR19945-296] (AB221547)

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Assay Kits

AB283996

Human Carbonic Anhydrase 14/CA14 ELISA Kit

Recombinant

Sandwich ELISA - Human Carbonic Anhydrase 14/CA14 ELISA Kit (AB283996)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cancer immunology, immunotherapy : CII 70:1213-1226 PubMed33119798

2020

B7-H3 confers resistance to Vγ9Vδ2 T cell-mediated cytotoxicity in human colon cancer cells via the STAT3/ULBP2 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Huimin Lu,Yanchao Ma,Mingyuan Wang,Jin Shen,Hongya Wu,Juntao Li,Nan Gao,Yanzheng Gu,Xueguang Zhang,Guangbo Zhang,Tongguo Shi,Weichang Chen

Oncoimmunology 9:1748991 PubMed32363121

2020

B7-H3 inhibits the IFN-γ-dependent cytotoxicity of Vγ9Vδ2 T cells against colon cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Huimin Lu,Tongguo Shi,Mingyuan Wang,Xiaomi Li,Yanzheng Gu,Xueguang Zhang,Guangbo Zhang,Weichang Chen
View all publications
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