AKIP overexpression 293T lysate (whole cell)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AKIP also known as A Kinase Interacting Protein plays a significant role in cellular functions. It interacts with protein kinase A (PKA) and is thought to have a molecular mass around 18 kDa. Expression of AKIP occurs in multiple tissues but it is especially noticeable in heart and brain tissues. It serves as a critical modulator by linking protein kinase A to different cellular compartments impacting various signaling pathways.

Biological function summary

AKIP functions to mediate cellular responses to hormonal changes. It forms part of an intricate protein complex that impacts the transcriptional regulation of genes by influencing PKA's function and localization. AKIP's interaction with PKA suggests its presence in processes related to cellular growth and apoptosis. Its regulatory action becomes important in maintaining certain cellular functions and promoting cell survival under stress conditions.

Pathways

AKIP involvement becomes evident in the cAMP signaling pathway. It modulates the pathway by directing PKA to distinct substrates affecting downstream effectors like CREB. This interaction regulates gene expression involved in metabolic processes. AKIP also shows connection to the MAPK signaling pathway contributing to cell growth and differentiation. Such pathways indicate AKIP’s role in orchestrating complex cellular interactions and signal transduction.

AKIP's altered expression has implications in cardiovascular diseases and cancer. Its interaction with PKA and downstream proteins like CREB links it to heart disease affecting cardiac cell signaling under stress conditions. In cancer AKIP associations with transcription factors lead to changes in cell proliferation and survival indicating its part in tumor development and progression. Understanding AKIP's unique roles in these conditions might provide opportunities for therapeutic interventions.