Bcl G/BCL2L14 overexpression 293T lysate (whole cell)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Bcl G also known as BCL2L14 is a protein part of the Bcl-2 family closely related to apoptosis regulation. It has a molecular mass of approximately 45 kDa. Bcl G expresses in various tissues with significant levels reported in the testis and lower levels observed in several other tissues like the brain liver and prostate. The protein exists in isoforms known as Bcl-G(L) and Bcl-G(S) with the former being more widely expressed.

Biological function summary

The function of this protein involves the regulation of apoptosis. Bcl G functions as a pro-apoptotic protein playing a role in cell death processes. Studies show that it can exist as part of larger complexes interacting with other Bcl-2 family proteins. This interaction usually influences mitochondrial pathways of apoptosis where Bcl G aids in mitochondrial membrane permeability changes leading to cell death.

Pathways

Bcl G significantly participates in the apoptosis pathway and the mitochondrial outer membrane permeabilization process. This protein interacts with several key regulatory proteins including Bcl-2 and Bax. These interactions modulate the release of cytochrome c from mitochondria a critical step in the intrinsic apoptosis pathway. Bcl G also aligns with the pathway for p53-mediated apoptosis further linking it to the cellular stress response.

Bcl G has associations with several forms of cancer. Research indicates a link between Bcl G expression and testicular cancer where it influences tumor progression and treatment response. In breast cancer Bcl G interacts with the well-known tumor suppressor p53 which suggests its role in tumor suppression and potential therapeutic target. Additionally mutations or altered expressions in this protein could disrupt normal apoptosis contributing to cancer development.