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Cytokeratin 19 overexpression 293T lysate (whole cell) suitable for WB. View our extensive range of validated lysates from normal and diseased human, mouse and rat tissue.

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Images

SDS-PAGE - Cytokeratin 19 overexpression 293T lysate (whole cell) (AB94061), expandable thumbnail
  • Western blot - Cytokeratin 19 overexpression 293T lysate (whole cell) (AB94061), expandable thumbnail

Key facts

Species or organism

Human

Form

Liquid

Alternative names

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Cytokeratin 19 overexpression 293T lysate (whole cell) suitable for WB. View our extensive range of validated lysates from normal and diseased human, mouse and rat tissue.

Key facts

Form

Liquid

Concentration
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Storage

Shipped at conditions

Dry Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

ab94061 is a 293T cell transfected lysate in which Human Cytokeratin 19 has been transiently over-expressed using a pCMV-Cytokeratin 19 plasmid. The lysate is provided in 1X Sample Buffer.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Cytokeratin 19 (CK19) also known as cytokera­tine 19 keratin 19 (KRT19) or CK19 is a type of intermediate filament found in epithelial cells. It serves as an essential component of the cytoskeleton. CK19 weighs approximately 40 kDa and is broadly expressed in simple epithelial tissues including liver intestine and various glandular epithelial cells. As a cytokeratin marker it often appears in combination with others like cytokeratin 17 in certain tissue types helping to maintain the structural integrity of cells.

Biological function summary

CK19 plays a role in maintaining the cytoskeletal framework that provides mechanical support and helps control cell size and shape. It is not part of a large protein complex but works closely with other cytokeratins to ensure the stability and resilience of epithelial tissues. The A53-B/A22.26 positive staining is often used to confirm its presence in clinical histopathology.

Pathways

CK19 connects to cellular processes especially involving the keratinization and epithelial cell differentiation pathways. It interacts with other cytokeratins including BA16 and KR17 to facilitate these processes. This interaction aids in modulating the dynamics of cytoskeletal rearrangement during cell movement division and differentiation.

Associated diseases and disorders

CK19 overexpression is linked with certain cancers notably hepatocellular carcinoma and breast cancer. It can serve as a prognostic marker in these diseases often in conjunction with other markers like CK17. The involvement of CK19 in the epithelial-mesenchymal transition (EMT) process connects it to the progression and aggressiveness of tumors facilitated by interactions with proteins involved in EMT pathways.

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2 product images

  • SDS-PAGE - Cytokeratin 19 overexpression 293T lysate (whole cell) (ab94061), expandable thumbnail

    SDS-PAGE - Cytokeratin 19 overexpression 293T lysate (whole cell) (ab94061)

    ab94061 at 15µg/lane on an SDS-PAGE gel.

  • Western blot - Cytokeratin 19 overexpression 293T lysate (whole cell) (ab94061), expandable thumbnail

    Western blot - Cytokeratin 19 overexpression 293T lysate (whole cell) (ab94061)

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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