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Dhh overexpression 293T lysate (whole cell) suitable for WB. View our extensive range of validated lysates from normal and diseased human, mouse and rat tissue.

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Key facts

Species or organism

Human

Form

Liquid

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Alternative names

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Dhh overexpression 293T lysate (whole cell) suitable for WB. View our extensive range of validated lysates from normal and diseased human, mouse and rat tissue.

Alternative names

Key facts

Form

Liquid

Concentration
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Storage

Shipped at conditions

Dry Ice

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

ab94180 is a 293T cell transfected lysate in which Human Dhh has been transiently over-expressed using a pCMV-Dhh plasmid. The lysate is provided in 1 x Sample Buffer.

Supplementary info

Biological function summary

Dhh contributes to the regulation of morphogenesis and tissue patterning. Dhh forms part of the Hedgehog signaling pathway a critical signaling complex needed for the communication between cells. This interaction is important for cellular processes such as growth survival and differentiation. The protein is critical in development and is significant for the proper formation of various organs and tissues.

Activity summary

The protein 'Desert Hedgehog' (Dhh) also known as DHH weighs approximately 42 kDa and plays an important role in signaling pathways. Dhh functions mechanically by sending signals that control cell growth and differentiation during embryonic development. This protein expresses in specific tissues such as the gonads and is especially associated with Sertoli cells in the testes.

Pathways

Its involvement with the Hedgehog signaling pathway is essential. This pathway impacts the development of several structures and organs by regulating gene expression. Other proteins involved in this pathway include Patched1 (PTCH1) and Smoothened (SMO). Pathway deregulation can lead to issues and is a significant area of study in several types of biological research.

Associated diseases and disorders

Dhh has links to conditions like gonadal dysgenesis and peripheral neuropathy. Abnormal function or expression of the Dhh protein can lead to developmental defects or contribute toward disease progression. The interaction with other proteins such as PTCH1 further highlights its involvement in the pathogenesis of these conditions. Understanding Dhh’s role offers potential insights into therapeutic interventions for these diseases.

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2 product images

  • SDS-PAGE - Dhh overexpression 293T lysate (whole cell) (ab94180), expandable thumbnail

    SDS-PAGE - Dhh overexpression 293T lysate (whole cell) (ab94180)

    ab94180 at 15μg/lane on an SDS-PAGE gel.

  • Western blot - Dhh overexpression 293T lysate (whole cell) (ab94180), expandable thumbnail

    Western blot - Dhh overexpression 293T lysate (whole cell) (ab94180)

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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