DR6 overexpression 293T lysate (whole cell)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DR6 also known as Death Receptor 6 or TNFRSF21 is a member of the tumor necrosis factor receptor superfamily. This protein has a mass of approximately 71 kDa and is expressed in a variety of tissues including the heart lymph nodes and spleen. DR6 functions as a transmembrane receptor and plays a critical role in mediating apoptosis and cellular communication.

Biological function summary

DR6 acts as a mediator in cell death signaling pathways. It associates with other proteins to form a death-inducing signaling complex triggering apoptotic pathways upon activation by specific ligands. DR6 is involved in regulating cell growth differentiation and survival. It also plays a role in modulating the immune response especially the adaptive immune response by influencing T-cell activation and proliferation.

Pathways

DR6 is involved in apoptosis and immune signaling pathways. It interacts with proteins such as caspases and adaptor proteins in the apoptotic pathways. In the immune system DR6 is related to proteins like TRAF family members which help in transmitting signals required for T-cell responses. DR6 influences several downstream effects that are critical for maintaining cellular homeostasis and immune regulation.

DR6 has been implicated in neurodegenerative diseases and cancer. Altered expression or function of DR6 can contribute to diseases such as Alzheimer's disease by promoting neuronal apoptosis. In cancer aberrant DR6 signaling may affect tumor cell survival and progression. DR6's interaction with amyloid precursor protein (APP) in neurodegenerative diseases and its association with certain tumor necrosis factor ligands in cancer highlight its significance in disease pathways.